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https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2765502/
Peptide-Functionalized Nanogels for Targeted siRNA Delivery. ... These promising preliminary studies clearly illustrate the efficacy of peptide-targeted delivery of siRNA cargos via nanogel carriers. The lack of toxicity observed is of particular interest, given the high toxicity observed for some cationic lipid-based siRNA targeting methods ...Author: William H. Blackburn, Erin B. Dickerson, Michael H. Smith, John F. McDonald, L. Andrew Lyon
https://pubs.acs.org/doi/abs/10.1021/bc800547c
A major bottleneck in the development of siRNA therapies is their delivery to the desired cell type or tissue, followed by effective passage across the cell membrane with subsequent silencing of the targeted mRNA. To address this problem, we describe the synthesis of core/shell hydrogel nanoparticles (nanogels) with surface-localized peptides that specifically target ovarian carcinoma cell ...Author: William H. Blackburn, Erin B. Dickerson, Michael H. Smith, John F. McDonald, L. Andrew Lyon
https://www.researchgate.net/publication/24252869_Peptide-Functionalized_Nanogels_for_Targeted_siRNA_Delivery
Request PDF Peptide-Functionalized Nanogels for Targeted siRNA Delivery A major bottleneck in the development of siRNA therapies is their delivery to the desired cell type or tissue, followed ...
https://experts.umn.edu/en/publications/peptide-functionalized-nanogels-for-targeted-sirna-delivery
title = "Peptide-functionalized nanogels for targeted siRNA delivery", abstract = "A major bottleneck in the development of siRNA therapies is their delivery to the desired cell type or tissue, followed by effective passage across the cell membrane with subsequent silencing of the targeted mRNA.Author: William H. Blackburn, Erin B. Dickerson, Michael H. Smith, John F. McDonald, L. Andrew Lyon
https://nanotechnologies.weebly.com/uploads/3/2/4/1/3241502/lyon1.pdf
Peptide-Functionalized Nanogels for Targeted siRNA Delivery William H. Blackburn, ⊥,†, ... siRNA delivery prevent widespread therapeutic use (16, 17). In addition to the confounding issues associated with systemic, intraveneous delivery of siRNA, its polyanionic nature and high
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2820460/
The results presented herein demonstrate the therapeutic delivery of gene-specific siRNA cargo using peptide-functionalized nanogels, with the subsequent reduction of EGFR expression and increased chemosensitivity to docetaxel as a highly effective strategy for …Author: Erin B Dickerson, William H Blackburn, Michael H Smith, Laura B Kapa, L Andrew Lyon, John F McDonald
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