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https://www.nature.com/articles/ncomms11980
Jun 28, 2016 · Peptide-conjugated nanoparticles were incubated with formalin-fixed frozen sections from injured and normal brains for ex vivo binding. Sections were counterstained with …Author: Aman P. Mann, Pablo Scodeller, Pablo Scodeller, Sazid Hussain, Jinmyoung Joo, Jinmyoung Joo, Ester K...
https://www.future-science.com/doi/10.2144/000113005
May 16, 2018 · These results suggest that Vivo-Morpholinos can enter cells in a system mimicking in vivo conditions, whereas the free delivery peptide, Endo-Porter, is unable to deliver bare Morpholino in the same conditions. Figure 2. Assessment of Vivo-Morpholino delivery in cultured HeLa cells grown in …
https://www.researchgate.net/publication/260395546_Efficient_in_vivo_gene_delivery_using_modified_Tat_peptide_with_cationic_lipids
Efficient in vivo gene delivery using modified Tat peptide with cationic lipids ... a cell-penetrating peptide is able to enhance the gene delivery, which results in rapid distribution of H5 in ...
https://www.nature.com/articles/nbt.3081
Oct 30, 2014 · Efficient protein delivery using cationic lipid transfection reagents enables high efficiency protein-based genome editing in vivo and in vitro. Efficient intracellular delivery of proteins is ...
https://pubs.acs.org/doi/10.1021/ja311180x
Cell-penetrating peptides (CPPs) such as transactivator of transcription (TAT) peptide have long been explored for promoting in vitro cell penetration and nuclear targeting of various cargos, but their positive charges cause strong nonspecific interactions, making them inapplicable for many in vivo applications. In this work, we used TAT to demonstrate a molecular modification approach for ...
https://gut.bmj.com/content/early/2019/08/09/gutjnl-2019-319146
Objective To fulfil an unmet therapeutic need for treating type 2 diabetes by developing an innovative oral drug delivery nanosystem increasing the production of glucagon-like peptide-1 (GLP-1) and the absorption of peptides into the circulation. Design We developed a nanocarrier for the oral delivery of peptides using lipid-based nanocapsules.
https://www.mdpi.com/1999-4923/11/11/568/htm
Cyclic cHAVc3 peptide was better than a linear HAV4 in improving in vivo brain delivery of gadopentetic acid (Gd-DTPA) as a magnetic resonance imaging (MRI) agent in mice as well as in lowering the TEER values of MDCK cell monolayers . One of the potential reasons for lower activity of cHAVc1 compared to that of cHAVc3 is that cHAVc1 has more ...
https://jnanobiotechnology.biomedcentral.com/articles/10.1186/s12951-020-0574-z
Jan 17, 2020 · The successful deliveries of siRNA depend on their stabilities under physiological conditions because greater in vivo stability enhances cellular uptake and enables endosomal escape. Viral-based systems appears as most efficient approaches for gene delivery but often compromised in terms of biocompatibility, patient safety and high cost scale up process. Here we describe a novel …
https://mcr.aacrjournals.org/content/8/2/135
Hepatocellular carcinoma is one of the deadliest cancers in the world. In this study, a hepatocarcinoma-specific binding peptide, which could be used for drug delivery in targeting therapy, was obtained by in vivo phage display technology. After three rounds of panning, only the potential motif Pro-Ser was found in 80 sequenced phage clones.
https://www.researchgate.net/publication/46190930_In_vivo_biodistribution_and_efficacy_of_peptide_mediated_delivery
Introduction: Delivery of nucleic acid-based molecules in human cells is a highly studied approach for the treatment of several disorders including monogenic diseases and cancers.
https://gut.bmj.com/content/gutjnl/early/2019/08/09/gutjnl-2019-319146.full.pdf
trigger endogenous GLP-1 secretion in vivo after oral adminis-tration in mice.12–14 However, despite these encouraging results and the promising properties attributed to nanomedicines, we need to prove that these novel formulations perform better than standard formulations incorporating functional excipients in oral peptide delivery.
http://onlinelibrary.wiley.com/doi/10.1002/adma.201200209/abstract
Self‐Assembled Peptide Amphiphile Micelles Containing a Cytotoxic T‐Cell Epitope Promote a Protective Immune Response In Vivo. Matthew Black. Department of Chemical Engineering, University of California, Santa Barbara, Santa Barbara, CA 93106, USA ... Ting Wang, Zhirong Zhang, Tao Gong and Xun Sun, Cationic micelle delivery of Trp2 peptide ...
https://www.polyplus-transfection.com/products/invivo-jetrna/
in vivo transfection reagents are the most powerful alternative to viral vectors for nucleic acid delivery. They are easy to use, cost-effective and considered as safe and efficient vehicles for RNA delivery. mRNA transfection is rapidly emerging as a promising method for nucleic acid-based therapy and offers an attractive substitute to plasmid DNA. Non-viral mRNA delivery methods have already ...
https://www.genengnews.com/magazine/297/optimizing-the-delivery-of-peptide-based-therapeutics/
Home July 1 2017 Vol. 37 No. 13 Feature Articles Optimizing the Delivery of Peptide-Based Therapeutics. ... in fact, behave in vivo like classical pharmaceuticals. Doses are in …
https://science.sciencemag.org/content/285/5433/1569.full
Currently, efficient delivery of therapeutic compounds, peptidyl mimetics, and proteins into cells in vivo can be achieved only when the molecules are small—typically less than 600 daltons ().Delivery of bioactive peptides across the blood-brain barrier, for example, is generally restricted to small (six amino acids or less), highly lipophilic peptides ().
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