Peptide-Based Delivery Of Steric-Block Pna Oligonucleotides

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Peptide-based delivery of steric-block PNA oligonucleotides.

    https://www.ncbi.nlm.nih.gov/pubmed/19085117
    Conjugation of steric-block neutral DNA mimics such as peptide nucleic acids (PNA) or phosphorodiamidate morpholino oligonucleotides (PMO) to cell penetrating peptides (CPP) has recently been proposed as a new delivery strategy.Author: Saïd Abes, Gabriela D. Ivanova, Rachida Abes, Andrey A. Arzumanov, Donna Williams, David Owen, Berna...

Peptide-Based Delivery of Steric-Block PNA Oligonucleotides

    https://www.researchgate.net/publication/23665886_Peptide-Based_Delivery_of_Steric-Block_PNA_Oligonucleotides
    Peptide nucleic acids (PNA) or phosphoramidate morpholino oligonucleotides (PMO) are particularly suited as steric block oligonucleotides in this respect.

Lipoplex and peptide-based strategies for the delivery of ...

    https://www.sciencedirect.com/science/article/pii/S0378517307003754
    Cationic lipids have been widely used for the delivery of charged oligonucleotide (ON) analogues but most of the commercial formulations are toxic and poorly stable in the presence of serum proteins.Author: Sarah Resina, Saïd Abes, John J. Turner, Paul Prevot, Adrian Travo, Philippe Clair, Michael J. Gait,...

Cell-penetrating-peptide-based delivery of ...

    https://portlandpress.com/biochemsoctrans/article/35/4/775/64115/Cell-penetrating-peptide-based-delivery-of
    CPP (cell-penetrating peptide)-based delivery of steric-block ONs is limited by endosome trapping CPPs, and Tat (transactivator of transcription) (48–60) protein transduction domain in particular, have been used largely for delivery of a vast collection of biomolecules.Author: R. Abes, A.A. Arzumanov, H.M. Moulton, S. Abes, G.D. Ivanova, P.L. Iversen, M.J. Gait, B. Lebleu

Peptide-based delivery of nucleic acids: Design, mechanism ...

    https://jhu.pure.elsevier.com/en/publications/peptide-based-delivery-of-nucleic-acids-design-mechanism-of-uptak-4
    Feb 01, 2007 · title = "Peptide-based delivery of nucleic acids: Design, mechanism of uptake and applications to splice-correcting oligonucleotides", abstract = "CPPs (cell-penetrating peptides) have given rise to much interest for the delivery of biomolecules such as peptides, proteins or ONs (oligonucleotides).Author: S. Abes, H. Moulton, J. Turner, P. Clair, Jean-Philippe Richard, P. Iversen, M. J. Gait, B. Lebleu

Evaluation of Cell-Penetrating Peptides (CPPs) as Vehicles ...

    https://pubs.acs.org/doi/10.1021/bc050283q
    Lipoplex and peptide-based strategies for the delivery of steric-block oligonucleotides. International Journal of Pharmaceutics 2007 , 344 (1-2) , 96-102. DOI: 10.1016/j.ijpharm.2007.04.039.Author: Nadia Bendifallah, Frank Winther Rasmussen, Vladimir Zachar, Peter Ebbesen, Peter E. Nielsen, Uffe K...

Cell-penetrating-peptide-based delivery of ...

    https://vetmed.oregonstate.edu/biblio/cell-penetrating-peptide-based-delivery-oligonucleotides-overview
    Cationic CPPs (cell-penetrating peptides) have been used largely for intracellular delivery of low-molecular-mass drugs, biomolecules and particles. Most cationic CPPs bind to cell-associated glycosaminoglycans and are internalized by endocytosis, although the detailed mechanisms involved remain controversial.

(PDF) Cell-penetrating-peptide-based delivery of ...

    https://www.researchgate.net/publication/6203568_Cell-penetrating-peptide-based_delivery_of_oligonucleotides_An_overview
    Cationic CPPs (cell-penetrating peptides) have been used largely for intracellular delivery of low-molecular-mass drugs, biomolecules and particles. Most cationic CPPs bind to cell-associated glycosaminoglycans and are internalized by endocytosis,...

Peptide Nanoparticle Delivery of Charge-Neutral Splice ...

    https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4376484/
    Apr 01, 2015 · Peptide Nanoparticle Delivery of Charge-Neutral Splice-Switching Morpholino Oligonucleotides. 1Medical Research Council, Laboratory of Molecular Biology, Cambridge Biomedical Campus, Cambridge, United Kingdom.Author: Peter Järver, Eman M. Zaghloul, Andrey A. Arzumanov, Amer F. Saleh, Graham McClorey, Suzan M. Hammon...

Efficient splicing correction by PNA conjugation to an R6 ...

    https://www.europepmc.org/articles/PMC1934994/
    Europe PMC is an archive of life sciences journal literature. Find the latest peer-reviewed research articles and preprints on Coronavirus here.

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