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https://www.sciencedirect.com/science/article/pii/S0169409X12002013
Peptide-based delivery to bone ... therefore a small peptide of repetitive amino acid could work as a carrier for selective drug delivery to bone. Using (Asp) 6 as the possible peptide, conjugated to FITC (fluorescein isothiocyanate) as a model compound, Kasugai et al. showed that small peptide conjugation is a possible way for drug targeting.Author: Kazuhiro Aoki, Neil Alles, Niroshani Soysa, Niroshani Soysa, Keiichi Ohya
https://www.researchgate.net/publication/227341376_Peptide-based_delivery_to_bone
Bone-targeted drug delivery is an active research area because successful clinical applications of this technology can significantly advance the treatment of bone injuries and disorders.
https://www.sciencedirect.com/science/article/pii/B978008100736500017X
Currently, there are several peptide-based formulations in clinical trials, but no peptide-based drug complexes are in clinical use. The development of novel peptide-based drug-delivery systems is essential for the standardization and benchmarking of highly efficient therapies.Author: Dana M. Copolovici, Andreea I. Lupitu
https://www.deepdyve.com/lp/elsevier/peptide-based-delivery-to-bone-LeZYkyEe8q
Sep 01, 2012 · Read "Peptide-based delivery to bone, Advanced Drug Delivery Reviews" on DeepDyve, the largest online rental service for scholarly research with thousands of academic publications available at your fingertips.
https://www.researchgate.net/publication/261375876_Peptide-Based_Delivery_of_Oligonucleotides_Across_Blood-Brain_Barrier_Model
bone interacting with cationic CPPs through electrostatic ... Peptide-based delivery vectors is an emerging tool as shuttles for drug delivery across the BBB and one may explore receptor-mediated ...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6359574/
Jan 19, 2019 · A dual behavior is observed: on the one hand they can fulfill a structural and bioactive role. In this review, we focus on the design and the characterization of drug delivery systems using peptide-based carriers; moreover, we will also highlight the peptide ability to self-assemble and to actively address nanosystems toward specific targets.Author: Diego Tesauro, Antonella Accardo, Carlo Diaferia, Vittoria Milano, Jean Guillon, Luisa Ronga, Filome...
https://www.genengnews.com/magazine/305/pepide-based-delivery-of-recombinant-proteins-and-nucleic-acids/
The IntraStem system, from Locate Therapeutics, uses glycosamino-glycans to help cell-penetrating peptides carry various cargos, such as recombinant proteins, into various cell types, such as stem ...
https://pubs.acs.org/doi/abs/10.1021/acsnano.5b07828
Antiosteoporosis gene-based drug development strategies are presently focused on targeting osteoblasts to either suppress bone loss or increase bone mass. Although siRNA/microRNA-based gene therapy has enormous potential, it is severely limited by the lack of specific cell-targeting delivery systems. We report an osteoblast-targeting peptide (SDSSD) that selectively binds to osteoblasts via ...Author: Yao Sun, Xiongzhen Ye, Mingxiang Cai, Xiangning Liu, Jia Xiao, Chenyang Zhang, Yayu Wang, Li Yang, J...
https://drug-dev.com/peptide-based-cancer-therapeutics/
Current Status & Future of Peptide Based Anti-Cancer Agents. The application of peptides as a direct therapeutic agent, in targeted drug delivery and as a diagnostic tool in cancer biology, is growing. Drug targeting exploits differences in the nature of normal and cancer cells and their microenvironment.
https://journals.sagepub.com/doi/10.1177/0022034516633170
Mar 22, 2016 · The supplementation of other bone-augmenting agents is considered helpful in preventing such side effects by reducing the amount of BMP-2 required to obtain a sufficient amount of bone. We recently showed that a receptor activator of nuclear factor κB ligand (RANKL)–binding peptide promotes osteoblast differentiation.Author: T. Uehara, S. Mise-Omata, M. Matsui, M. Matsui, Y. Tabata, R. Murali, M. Miyashin, K. Aoki
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