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https://www.researchgate.net/publication/7914996_PEG-phospholipid_micelles_for_the_delivery_of_amphotericin_B
Micelles formed from PEG-DSPE solubilize high levels of the poorly water-soluble antifungal amphotericin B (AmB). AmB release from PEG-DSPE micelles is slow in …
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4624226/
Amphotericin B/Sterol Co-loaded PEG-Phospholipid Micelles: Effects of Sterols on Aggregation State and Hemolytic Activity of Amphotericin B Thomas A. Diezi 1 and Glen Kwon 1, 2 1 School of Pharmacy, University of Wisconsin, Madison, WIAuthor: Thomas A. Diezi, Glen Kwon
https://www.ncbi.nlm.nih.gov/pubmed/22130733
Amphotericin B/sterol co-loaded PEG-phospholipid micelles: effects of sterols on aggregation state and hemolytic activity of amphotericin B. Diezi TA(1), Kwon G. Author information: (1)University of Wisconsin, Madison, Wisconsin, USA.Author: Thomas A. Diezi, Glen Kwon
https://pubs.acs.org/doi/10.1021/mp700081v
Micelles formed from PEG-DSPE solubilize high levels of the poorly water-soluble antifungal amphotericin B (AmB). AmB release from PEG-DSPE micelles is slow in buffer but remarkably rapid in the presence of bovine serum albumin (BSA).Author: Ronak Vakil, Glen S. Kwon
https://link.springer.com/article/10.1007/s11095-011-0626-z
Dec 01, 2011 · To elucidate the effect of sterols on the aggregation of amphotericin B (AmB) in PEG-phospholipid micelles and its consequences on the hemolytic activity of AmB. AmB-incorporated PEG-phospholipid micelles co-loaded with ergosterol, cholesterol, or 7-dehydrocholesterol were prepared at 4:1:1 and 20:5:1 ratios of polymer-to-sterol-to-AmB.Author: Thomas A. Diezi, Glen Kwon
https://www.aspergillus.org.uk/content/polymeric-micelles-solubilization-and-delivery-amphotericin-b
PEG-b -PHSA micelles did not show marked differences in pharmacokinetics, relative to a commercial AmB formulation, yet nephrotoxicity was significantly reduced. The reduced kidney toxicity may be related to the deaggregation state of AmB in PEG- b -PHSA micelles. AmB incorporated PEG-phospholipid micelles co-loaded with core-stabilizing ergosterol, cholesterol, or 7-dehydrocholesterol or no sterol…
https://www.sciencedirect.com/science/article/pii/S0168365910004438
Angiopep-2 modified PE-PEG based polymeric micelles for amphotericin B delivery targeted to the brain Author links open overlay panel Kun Shao a Rongqin Huang a Jianfeng Li a Liang Han a Liya Ye b Jinning Lou b Chen Jiang aAuthor: Kun Shao, Rongqin Huang, Jianfeng Li, Liang Han, Liya Ye, Jinning Lou, Chen Jiang
http://europepmc.org/patents/PAT/US2010210575
Embodiments also relate to the controlled release of pharmaceutical agents in the context of drug delivery. Further disclosed are embodiments of PEG-DSPE/ Cholesterol micelle formulations prepared with an antifungal agent, Amphotericin B, with capabilities including slow release of the agent in a deaggregated state.
https://patents.google.com/patent/US20100210575A1/en
Embodiments also relate to the controlled release of pharmaceutical agents in the context of drug delivery. Further disclosed are embodiments of PEG-DSPE/Cholesterol micelle formulations prepared with an antifungal agent, Amphotericin B, with capabilities including slow release of the agent in a deaggregated state.Author: Glen S. Kwon, Ronak J. Vakil
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