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http://www.freepatentsonline.com/y2010/0076209.html
Mar 25, 2010 · Liposomes incorporating PEG-lipid conjugates of the present invention may be used to encapsulate and deliver a wide variety of active agents since the liposomes include an enclosed aqueous space, a hydrophobic region in the bilayer, and sites for covalent attachment.
https://patents.google.com/patent/US8304565B2/en
US8304565B2 - PEG-lipid conjugates for liposomes and drug delivery - Google Patents New diacylglycerol-polyethylene glycol (DAG-PEG) conjugates are described. A variety of linkers between the PEG...Author: Nian Wu, Brian Charles Keller
http://europepmc.org/patents/PAT/US2010076209
New diacylglycerol-polyethylene glycol (DAG-PEG) conjugates are described. A variety of linkers between the PEG chain and glycerol backbone of the DAG-PEGs may be selected to optimize liposomal formulations of pharmaceuticals and cosmetics.
https://avantilipids.com/images/ProductLiterature/PEG_Lipid_Conjugates.pdf
Poly(Ethylene Glycol)-Lipid Conjugates Polyethylene glycol (PEG)-lipid conjugates have been used extensively to improve circulation times for liposome encapsulated drugs, including doxorubicin 1,2 , mitoxantrone 3 , and the lipophilic prodrug of 5-fluorodeoxyuridine. 4 Recently, new applications have been developed using PEGylated liposomes.
https://www.sciencedirect.com/science/article/pii/0169409X95000275
Interaction of PEG-phospholipid conjugates with phospholipid: implications in liposomal drug delivery. Abstract. Mixtures of PEG-phospholipid conjugates and phosphatidylcholine show mainly three different physical states: lamellar phase with components exhibiting some miscibility, lamellar phase with components phase separated and mixed micelles.Author: Frank K. Bedu-Addo, Leaf Huang
https://www.sciencedirect.com/science/article/pii/S1773224718310086
Addition of polyethylene glycol polymer (PEG)-lipid conjugate into the lipid membrane of the liposome, is one method of enhancing the efficacy of the liposome system by prolonging the circulation time of the liposomes in the blood which provides a steric effect against interactions between the liposomes and the plasma proteins of the blood .Author: Pensri Charoensit, Wilart Pompimon, Nantaka Khorana, Srisagul Sungthongjeen
https://pubs.acs.org/doi/full/10.1021/bi952000v
Enhanced gene delivery efficiency of cationic liposomes coated with PEGylated hyaluronic acid for anti P-glycoprotein siRNA: A potential candidate for overcoming multi-drug resistance. International Journal of Pharmaceutics 2014 , 477 (1-2) , 590-600.Author: John W. Holland, Cathy Hui, Pieter R. Cullis, Thomas D. Madden
https://www.sciencedirect.com/science/article/pii/S0168365914004556
PEG — A versatile conjugating ligand for drugs and drug delivery systems. ... chemical modification and novel delivery systems such as liposomes, microspheres, ... J. McGuire, C.D. ConoverEffective drug delivery by PEGylated drug conjugates. Adv. Drug Deliv. Rev., 55 …Author: Atul Kolate, Dipesh Baradia, Sushilkumar Patil, Imran Vhora, Girish Kore, Ambikanandan Misra
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4051498/
Furthermore, we feel that the accumulating evidence documenting the detrimental effects of PEG on drug delivery make it imperative that scientists in this field break their dependence on PEGylation, and develop improved approaches for achieving adequate circulation times in order to realize the enormous clinical benefits of targeted drug delivery.Author: Johan J. F. Verhoef, Thomas J. Anchordoquy
https://www.researchgate.net/publication/261918865_Recent_development_of_polyethylene_glycol-cholesterol_conjugates_as_drug_delivery_systems
Poly (ethylene glycol) (PEG) cholesterol conjugates (PEG-Ch) had been developed to enhance the stability and activity of liposomes and other lipid-based drug delivery systems [7][8][9].
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