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https://www.sciencedirect.com/science/article/pii/B9780123849649000116
To formulate an effective parenteral delivery system for proteins and peptides, the pharmacokinetic profile of the P/P drug must be considered . In P/P drugs, the bioavailability is reduced from subcutaneous injection due to proteolytic degradation at the site of injection.Author: Himanshu Agrawal, Nipa Thacker, Ambikanandan Misra
https://www.tandfonline.com/doi/abs/10.1080/03639045.2019.1628770
As most of the commercial products for proteins and peptides are available as a parenteral delivery and freeze drying process is one commonly used technique, it is imperative to understand the complex steps of development for better and faster product development.Author: Divisha Jain, S. Shahe Mahammad, Pirthi Pal Singh, Ravinder Kodipyaka
https://www.sciencedirect.com/book/9780123849359/peptide-and-protein-delivery
As proteins and peptides are complex and fragile molecules, there are formulation challenges that need to be overcome. Knowledge in this field is continually progressing and inhalation will become a convenient administration method for proteins and peptides, particularly for local delivery, in the future.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4130463/
PEGylation. PEGylation is the most extensively studied approach for delivery of various proteins and peptides via parenteral routes. It exploits covalent conjugation of activated PEG to the therapeutic proteins or peptides of interest.Author: Ashaben Patel, Kishore Cholkar, Ashim K Mitra
https://www.researchgate.net/publication/333880689_A_Review_on_Parenteral_Delivery_of_Peptides_and_Proteins
As most of the commercial products for proteins and peptides are available as a parenteral delivery and Freeze drying process is one commonly used technique, it is imperative to understand the ...
https://www.researchgate.net/publication/285179323_Parenteral_Delivery_of_Peptides_and_Proteins
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http://www.authorstream.com/Presentation/pharmawick-1969759-protein-peptide-drug-delivery/
Oct 24, 2013 · CONTENTS 2 Protein & Peptides. Structure of protein. Classification of protein. Importance of protein and peptide drugs. Advantages and disadvantages and stability problems. Parenteral delivery of protein and peptide drug delivery. non parenteral delivery of protein and peptide drug delivery. Marketed formulations . Conclusion. References.
https://www.cell.com/trends/biotechnology/fulltext/S0167-7799(09)00143-7
Sep 21, 2009 · In the past, non-parenteral administration of peptides and proteins was believed to be impossible. Nowadays, with the development of the different formulation approaches discussed above, the obstacles for effective delivery of peptide and protein therapeutics have been slowly overcome.Author: Zuzana Antosova, Martina Mackova, Vladimir Kral, Tomas Macek
https://epub.uni-regensburg.de/8515/1/ubr04037_ocr.pdf
tion of controlled release devices for such proteins and peptides has, there fore, become one of the major challenges in the field of controlled release. Controlled release devices have been prepared for various routes of administration such as oral, parenteral, nasal, rectal, buccal, vaginal and transdermal(6-7).
https://innovareacademics.in/journal/ijcpr/Issues/Vol3Issue2/286.pdf
(1) Parenteral systemic delivery: (3) For the systemic delivery of therapeutic peptides and proteins, parenteral administration is currently believed to be the most efficient route and also the delivery method of choice to achieve therapeutic activity. Parenteral delivery consist of …
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