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https://www.tandfonline.com/doi/abs/10.1080/03639045.2019.1628770
As most of the commercial products for proteins and peptides are available as a parenteral delivery and freeze drying process is one commonly used technique, it is imperative to understand the complex steps of development for better and faster product development.Author: Divisha Jain, S. Shahe Mahammad, Pirthi Pal Singh, Ravinder Kodipyaka
https://www.sciencedirect.com/science/article/pii/B9780123849649000116
To formulate an effective parenteral delivery system for proteins and peptides, the pharmacokinetic profile of the P/P drug must be considered. In P/P drugs, the bioavailability is reduced from subcutaneous injection due to proteolytic degradation at the site of injection.Author: Himanshu Agrawal, Nipa Thacker, Ambikanandan Misra
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4130463/
PEGylation is the most extensively studied approach for delivery of various proteins and peptides via parenteral routes. It exploits covalent conjugation of activated PEG to the therapeutic proteins or peptides of interest.Author: Ashaben Patel, Kishore Cholkar, Ashim K Mitra
http://www.authorstream.com/Presentation/pharmawick-1969759-protein-peptide-drug-delivery/
Oct 24, 2013 · Emulsions based delivery: Emulsions can be used for parenteral drug delivery of proteins and peptides used to prolong the release of drug. e.g. subcutaneous administration of muramyl dipeptide in a w/o emulsion. It is used to potentiate immune system .
https://www.sciencedirect.com/science/article/pii/B9780128179093000169
Various protein/peptide drug delivery systems have been extensively investigated to overcome the problems associated with the exogenous administration of protein and peptide therapeutics. In this chapter, different approaches for the delivery of proteins and peptides are discussed including chemical modifications, absorption enhancers, carrier ...Author: Pran Kishore Deb, Omar Al-Attraqchi, Balakumar Chandrasekaran, Anant Paradkar, Rakesh K. Tekade
http://www.authorstream.com/Presentation/gunjankapoor25-1285615-types-of-proteins-and-peptides/
Dec 21, 2011 · Parenteral Route Of Administration For the systemic release of the protein and peptides parenteral route is the most efficient route. This is the best choice to achieve the therapeutic activity. Mainly three types of administration are used: 1) Intravascular 2…
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