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https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4787057/
Insulin delivery methods: Past, present and future. ... insulin pens, and insulin pumps. Though subcutaneous insulin delivery is the standard route of insulin administration, it is associated with injection pain, needle phobia, lipodystrophy, noncompliance and peripheral hyperinsulinemia. ... The intravenous route was the first parenteral route ...
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https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4130463/
Currently, marketed protein and peptide drugs are mostly administered by parenteral routes such as subcutaneous (s.c.), intramuscular or intravenous (i.v.) injections. In contrast to oral and pulmonary delivery, parenteral delivery can avoid biological barriers. However, there are several limitations to parenteral protein and peptide delivery .Author: Ashaben Patel, Kishore Cholkar, Ashim K Mitra
https://clinicalgate.com/parenteral-drug-delivery/
• Parenteral preparations are administered to a patient by injection. • The medicine may be injected into the vascular system, into muscle or soft tissue to provide a systemic action, or into an anatomical space such as a joint or into a particular organ to provide a local action. • Medicines are administered by injection because the drug substance may not be absorbed orally, because a ...
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