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https://www.sciencedirect.com/science/article/pii/S2352940718301641
PAMAM dendrimer based targeted gene delivery Gene therapy requires special methods to deliver nucleic acids into the targeted cells and tissues. This is because nucleic acids have a pronounced negative charge due to the phosphate groups linking the …Author: Fereydoon Abedi-Gaballu, Fereydoon Abedi-Gaballu, Gholamreza Dehghan, Maryam Ghaffari, Maryam Ghaffa...
https://www.sciencedirect.com/science/article/pii/S0169409X05001936
The first exploration of dendrimers as molecules for gene delivery focused on the PAMAM dendrimers [21]. The PAMAM dendrimers are normally based on an ethylenediamine or ammonia core with four and three branching points, respectively [34], [35], [36].Author: Christine Dufès, Ijeoma F. Uchegbu, Andreas G. Schätzlein
https://pubs.acs.org/doi/10.1021/cr500542t
May 06, 2015 · Gene Delivery by PAMAM Dendrimer Conjugated with the Nuclear Localization Signal Peptide Derived from Influenza B Virus Nucleoprotein. Macromolecular Research 2019, 27 (4) , 360-368. DOI: 10.1007/s13233-019-7057-9.Author: Jiepin Yang, Qiang Zhang, Hong Chang, Yiyun Cheng
https://www.sciencedirect.com/science/article/pii/S0378517318303557
Poly (amidoamine) (PAMAM) dendrimers are well-defined, highly branched macromolecules with numerous active amine groups on the surface. Because of their unique properties, PAMAM dendrimers have steadily grown in popularity in drug delivery, gene therapy, medical imaging and …Author: Jun Li, Huamin Liang, Jing Liu, Ziyuan Wang
https://www.sciencedirect.com/science/article/pii/S1742706116303300
5. PEGylated PAMAM dendrimer in gene delivery. Gene delivery to the brain is highly challenging due to the blood-brain barrier (BBB). A novel brain-targeting gene vector based nanocarriers system was designed to bypass BBB using highly branched PAMAM dendrimer , . Transferrin (Tf) was selected as a model brain-targeting ligand and was conjugated to PAMAM using bifunctional PEG, resulting in PAMAM-PEG-Tf.Author: Duy Luong, Prashant Kesharwani, Rahul Deshmukh, Mohd Cairul Iqbal Mohd Amin, Umesh Gupta, Khaled Gre...
https://www.sciencedirect.com/science/article/pii/S1549963409000094
Although different studies have shown that PAMAM dendrimers can bind genetic material and facilitate gene transfer to a wide variety of cells,6, 7, 13 the use of PAMAM-DNA dendrimers for efficient gene delivery to liver and colon cancer cells in the presence of high concentrations of serum to mimic in vivo conditions has not been elucidated.Author: Gemma Navarro, Conchita Tros de ILarduya
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6278347/
Nov 02, 2018 · Dendrimers as a non-virus mediated gene delivery system have also been used extensively in the fields of neuroscience [79,107], cancer [108,109], and tissue reparation , among others .Author: Renan Vinicius de Araújo, Soraya da Silva Santos, Elizabeth Igne Ferreira, Jeanine Giarolla
https://www.europepmc.org/articles/PMC2773017/
Sep 01, 2009 · Triazine dendrimers as nonviral gene delivery systems: effects of molecular structure on biological activity. Find the latest peer-reviewed research articles and preprints on Coronavirus here. Feedback Complete survey. Sign in or create an account. https ...Author: Olivia M. Merkel, Meredith A. Mintzer, Johannes Sitterberg, Udo Bakowsky, Eric E. Simanek, Thomas Ki...
https://www.dissertationtopic.net/doc/1857331
The development of gene therapy provides opportunities to solve these problems. Coating transfectable gene vectors into the materials to build gene activated matrices has been considered a new strategy in regenerative medicine. As the matrices degrede, the vectors will be delivered to transfect cells and express the encoded growth factors.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6431889/
Therefore, its overall cationic nature and functionality make the PAMAM dendrimer a suitable candidate for gene delivery applications [13,14,15]. However, unmodified PAMAM dendrimers have low transfection efficiency compared with the gold standard polymer PEI 25 kD [ 16 ].Author: Seulgi Lee, Sang Jae Son, Su Jeong Song, Tai Hwan Ha, Joon Sig Choi
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