We have collected information about Oral Protein Drug Delivery for you. Follow the links to find out details on Oral Protein Drug Delivery.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2792531/
Thus, we can achieve site-specific drug delivery by the use of mucoadhesive polymeric system. Mucoadhesive polymers are able to adhere to the mucin layer on the mucosal epithelium and thus results in the increase of oral drug bioavailability of protein and peptide drugs.
https://link.springer.com/content/pdf/10.1208%2Fs12249-019-1325-z.pdf
protein polypeptide drug. BARRIERS TO ORAL DELIVERY OF PROTEIN AND PEPTIDE DRUG NPS Most of the protein and peptide drugs are macromolec-ular hydrophilic, in the extreme environment of gastrointes-tinal stability, susceptible to gastric acid and pepsin degradation; at the same time, because of its hydrophilicity,Author: Shu-jun Cao, Shuo Xu, Hui-ming Wang, Yong Ling, Jiahua Dong, Rui-dong Xia, Xiang-hong Sun
https://www.sciencedirect.com/science/article/pii/S1319016414000590
Oral delivery systems for proteins and peptides are still in development stages. Oral delivery, being non-invasive, is the most favored route of drug administration. This is illustrated by the fact that oral delivery represents approximately US$ 25 billion worldwide (Werle et al., 2007).Author: Abdul Muheem, Faiyaz Shakeel, Mohammad Asadullah Jahangir, Mohammed Anwar, Neha Mallick, Gaurav Kuma...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3956587/
As oral delivery improves patient compliance, there is great interest in the development of systems that allow for the oral delivery of peptide and protein therapeutics . This review will summarize the barriers to various noninvasive delivery methods with a focus on oral and transdermal delivery.Author: Benjamin J Bruno, Geoffrey D Miller, Carol S Lim
https://pubs.acs.org/doi/10.1021/bm060065f
A review of biodegradable polymeric systems for oral insulin delivery. Drug Delivery 2016, 99, 1-10. DOI: 10.3109/10717544.2015.1052863. Songfeng Liu, Jianhui Zhang, Xuejun Cui, Yachen Guo, Xiaoming Zhang, Wang Hongyan. Synthesis of chitosan-based nanohydrogels for loading and release of 5 …Author: Feng Qian, Fuying Cui, Jieying Ding, Cui Tang, Chunhua Yin
https://www.oramed.com/technology/
Drug availability is further secured by an absorption enhancer supplement that facilitates protein passing across the intestinal barrier. By preventing protein-drug breakdown in the gastrointestinal tract and promoting its crossing the small intestine, this breakthrough solution brings oral protein-drug delivery significantly closer to a reality.
https://www.ondrugdelivery.com/review-oral-peptide-delivery/
PROTEIN ORAL DELIVERY TECHNOLOGY POD ™ POD technology developed by Oramed (Jerusalem, Israel), consists of enteric-coated capsules containing an oily suspension of the peptide drug, an enzyme inhibitor, such as soy bean trypsin inhibitor, aprotinin and an absorption enhancer such as EDTA or bile salt, in omega-3 fatty acids.
https://www.sciencedirect.com/science/article/pii/S1359644606003084
To develop and improve oral delivery systems with such properties, the focus should be on the development of superior materials and delivery carriers for oral bioactive macromolecular drug delivery systems. The oral route for peptide and protein drug delivery might be possible in the near future using innovative delivery systems.Author: Mariko Morishita, Nicholas A. Peppas
https://www.researchgate.net/publication/40834786_Protein_and_Peptide_Drug_Delivery_Oral_Approaches
Designing means to deliver peptide and protein drugs successfully to the systemic circulation by the oral route has been a challenge to scientists in drug delivery for many years [1].
https://www.tandfonline.com/doi/figure/10.1517/17425247.2014.917077
However, oral bioavailabilities remain low and variable therefore high, potentially toxic doses of peptide/protein drugs are needed to elicit a therapeutic effect leading to high cost of the final product. There is very little research into larger proteins, making their oral delivery unlikely in the near future.Author: Alice L Smart, Simon Gaisford, Abdul W Basit
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