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https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2792531/
Designing oral peptide and protein delivery systems has been a persistent challenge to pharmaceutical scientists because of their several unfavorable physicochemical properties including large molecular size, susceptibility to enzymatic degradation, short plasma half-life, ion permeability, immunogenicity, and the tendency to undergo ...
https://www.sciencedirect.com/science/article/pii/S1319016414000590
Oral delivery systems for proteins and peptides are still in development stages. Oral delivery, being non-invasive, is the most favored route of drug administration. This is illustrated by the fact that oral delivery represents approximately US$ 25 billion worldwide (Werle et al., 2007).Author: Abdul Muheem, Faiyaz Shakeel, Mohammad Asadullah Jahangir, Mohammed Anwar, Neha Mallick, Gaurav Kuma...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3956587/
As oral delivery improves patient compliance, there is great interest in the development of systems that allow for the oral delivery of peptide and protein therapeutics . This review will summarize the barriers to various noninvasive delivery methods with a focus on oral and transdermal delivery.Author: Benjamin J Bruno, Geoffrey D Miller, Carol S Lim
https://pubs.acs.org/doi/10.1021/bm060065f
Advance in oral delivery systems for therapeutic protein. Journal of Drug Targeting 2019, 27 (3) , 283-291. DOI: 10.1080/1061186X.2018.1486406. Javed Iqbal, Gautam Behl, Gavin Walker, Chris Edin, Parveen Kumar, Niall O’Reilly, Rohit Bhatia, Laurence Fitzhenry, Taruna Arora. Nanoparticulate drug delivery systems for the oral administration of ...Author: Feng Qian, Fuying Cui, Jieying Ding, Cui Tang, Chunhua Yin
https://www.sciencedirect.com/topics/pharmacology-toxicology-and-pharmaceutical-science/oral-drug-delivery
Oral Drug Delivery. Oral drug delivery (ODD) is the most preferred and convenient route of drug administration due to high patient compliance, cost-effectiveness, least sterility constraints, flexibility in the design of dosage form and ease of production.
https://www.researchgate.net/publication/258149324_Properties_and_formulation_of_oral_drug_delivery_systems_of_protein_and_peptides
Properties and formulation of oral drug delivery systems of protein and peptides Article (PDF Available) in Indian Journal of Pharmaceutical Sciences 69(6):741-747 · December 2007 with 2,642 Reads
https://www.slideshare.net/YaminiShah/protein-and-peptide-delivery-system
Mar 22, 2016 · Protein and peptide delivery system ... is not problem but need for daily injections of insulin has in itself driven many researchers to develop non invasive protein delivery mainly oral and pulmonary Inhalable insulin marketed by Pfizer inc. under the name of Exubera was launched in 2006.But after around a year was removed from the market ...
https://www.tandfonline.com/doi/abs/10.1080/1061186X.2018.1486406
Jul 20, 2013 · Oral delivery is the most common method of drug administration with high safety and good compliance for patients. However, delivering therapeutic proteins to the target site via oral route involves tremendous challenge due to unfavourable conditions like biochemical barrier, mucus barrier and epithelial barriers.Author: Shiming He, Zhongcheng Liu, Donggang Xu
https://techtransfer.universityofcalifornia.edu/NCD/24189.html
Innovative large-molecule medicines face daunting limitations to benefit patients due to problems with delivery to the body. Current oral delivery of protein-based drugs, such as insulin, are denatured by digestive enzymes and suffer from poor gastrointestinal mucus permeability, which leads to unacceptably low drug bioavailability and therapeutic efficacy.
https://link.springer.com/content/pdf/10.1208%2Fs12249-019-1325-z.pdf
protein polypeptide drug. BARRIERS TO ORAL DELIVERY OF PROTEIN AND PEPTIDE DRUG NPS Most of the protein and peptide drugs are macromolec-ular hydrophilic, in the extreme environment of gastrointes-tinal stability, susceptible to gastric acid and pepsin degradation; at the same time, because of its hydrophilicity,Author: Shu-jun Cao, Shuo Xu, Hui-ming Wang, Yong Ling, Jiahua Dong, Rui-dong Xia, Xiang-hong Sun
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