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https://www.researchgate.net/publication/328265448_PROTEIN_AND_PEPTIDE_DRUG_DELIVERY_SYSTEM
The Protein and P eptide Drug Delivery system is important for the Oral Delivery of Protein and Peptides can be successfully achieved by using various carrier systems are like 1.
https://www.nih.gov/news-events/nih-research-matters/bone-building-protein-delivered-orally-mice-using-plants
A team led by Dr. Henry Daniell from the University of Pennsylvania has been testing plants as an oral delivery system for protein-based drugs. In a new study, they engineered the gene for a novel form of IGF-1 into the chloroplasts of lettuce plants. Chloroplasts, which convert sunlight into food for plants, pass through the stomach unharmed.
https://www.tandfonline.com/doi/abs/10.1080/1061186X.2018.1486406
Oral delivery is the most common method of drug administration with high safety and good compliance for patients. However, delivering therapeutic proteins to the target site via oral route involves tremendous challenge due to unfavourable conditions like biochemical barrier, mucus barrier and epithelial barriers.
https://pubs.acs.org/doi/10.1021/bm060065f
Improved oral bioavailability of alendronate via the mucoadhesive liposomal delivery system. European Journal of Pharmaceutical Sciences 2012, 46 (5) , 500-507. DOI: 10.1016/j.ejps.2012.04.002. T.A. Sonia, Chandra P. Sharma. An overview of natural polymers for oral insulin delivery.
https://www.youtube.com/watch?v=IamdkBcQH0Q
Apr 28, 2016 · suggested design for modification of solid lipid nano-particles modified by stearic acid octaarginine for oral drug delivery of proteins. ... Transdermal Drug Delivery System ... The Making of ...Author: samar yousef
https://link.springer.com/article/10.1208/s12249-019-1325-z
May 20, 2019 · The status, advantages, and disadvantages of various strategies are systematically analyzed. The systematic and personalized design of various factors affecting the release and absorption of drugs based on nanoparticles is pointed out. It is expected to design a protein peptide oral delivery system that can be applied in the clinic.
https://www.oramed.com/technology/
THE SOLUTION. Oramed Pharmaceuticals’ POD™ (Protein Oral Delivery) technology has been designed to (1) protect orally delivered proteins from detrimental enzymatic activity within the gastrointestinal tract and (2) to enhance their absorption across the intestinal wall.
https://www.ijpsonline.com/articles/properties-and-formulation-of-oral-drug-delivery-systems-of-protein-and-peptides.html
Mar 20, 2006 · On the basis of the nature of protein, various approaches can be explored to formulate the oral protein drug delivery system. Table 5: Approaches of formulation of oral protein drug delivery system [81]. General method for production of protein formulations are emulsification, coacervation, extrusion, spray drying and polymerization.
http://www.iptonline.com/articles/public/IPTNINE106NoPrint.pdf
Oral delivery of insulin This conjugated protein is known as hexyl insulin monoconjugate 2 (HIM2), and is the first successfully delivered oral dosage form of insulin to show good oral bioefficacy in humans. This ACE has been studied in Phase I and II clinical trials in …
https://en.wikipedia.org/wiki/Drug_delivery
Drug delivery is often approached via a drug's chemical formulation, but it may also involve medical devices or drug-device combination products. Drug delivery is a concept heavily integrated with dosage form and route of administration, the latter sometimes even being considered part of the definition.
https://www.nature.com/articles/nrd.2018.183
Nov 30, 2018 · A review of advanced oral drug delivery technologies facilitating the protection and absorption of protein and peptide molecules. Biotechnol. Adv. 32 , 1269–1282 (2014).
https://www.hindawi.com/journals/jphar/2018/9285854/
The development of nanoparticles drug delivery system is accepted to play major role in treatment of various life-threatening diseases as it provides safe, effective, and stable therapeutics effects, whereas protein nanoparticles hold promising results in nasal, pulmonary, oral, and ocular delivery, nonviral gene delivery, blood brain barrier ...
http://news.mit.edu/2019/pill-deliver-insulin-orally-0207
The MIT team is now continuing to work with Novo Nordisk to further develop the technology and optimize the manufacturing process for the capsules. They believe this type of drug delivery could be useful for any protein drug that normally has to be injected, such as immunosuppressants used to treat rheumatoid arthritis or inflammatory bowel ...
https://www.youtube.com/watch?v=mDn_UDikR1Y
Jan 12, 2016 · Oral Drug Delivery Oral Insulin Oral Drug Delivery System Oral Drug Delivery Technology Oral Drug Delivery Platform Oral Protein Delivery System Oral Peptide Delivery System Oral Biologics Oral ...
https://science.sciencemag.org/content/363/6427/611.full
Oral delivery is the simplest and least invasive way to deliver many pharmaceuticals, but many drugs and medications, including insulin, cannot survive passage through the stomach or the gastrointestinal tract. Abramson et al. developed an ingestible delivery vehicle that could self-reorient from any starting position so as to attach to the gastric wall. Encapsulation of a spring in a sugar ...
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