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https://www.sciencedirect.com/science/article/pii/S1319016414000590
Oral delivery systems for proteins and peptides are still in development stages. Oral delivery, being non-invasive, is the most favored route of drug administration. This is illustrated by the fact that oral delivery represents approximately US$ 25 billion worldwide (Werle et al., 2007).Author: Abdul Muheem, Faiyaz Shakeel, Mohammad Asadullah Jahangir, Mohammed Anwar, Neha Mallick, Gaurav Kuma...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4908063/
Jun 16, 2014 · A review on the strategies for oral delivery of proteins and peptides and their clinical perspectives. ... The current article deals with the possibilities being explored in the oral delivery of protein and peptide therapeutics, the challenges in their development and the current and future prospects, with focus on technology trends in the ...Author: Abdul Muheem, Faiyaz Shakeel, Mohammad Asadullah Jahangir, Mohammed Anwar, Neha Mallick, Gaurav Kuma...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3956587/
As oral delivery improves patient compliance, there is great interest in the development of systems that allow for the oral delivery of peptide and protein therapeutics . This review will summarize the barriers to various noninvasive delivery methods with a focus on oral and transdermal delivery.Author: Benjamin J Bruno, Geoffrey D Miller, Carol S Lim
http://www.eurekaselect.com/93278
The need for oral protein formulations has been recognized by researchers of various scientific disciplines and a number of patents have been filed that deal with technologies capable of facilitating oral protein delivery. Within the current review, patents based on approaches such as particulate delivery systems, multifunctional polymers, enzyme inhibitors, permeation enhancers and ligand-specific …Author: Martin Werle, Abdallah Makhlof, Hirofumi Takeuchi
https://www.nature.com/articles/nrd.2018.183
Nov 30, 2018 · A review of advanced oral drug delivery technologies facilitating the protection and absorption of protein and peptide molecules. Biotechnol. Adv. 32 , 1269–1282 (2014).Author: Aaron C. Anselmo, Yatin Gokarn, Samir Mitragotri
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2792531/
The main challenge is to improve the oral bioavailability from less than 1% to at least 30-50%. Consequently, efforts have intensified over the past few decades, where every oral dosage form used for the conventional small molecule drugs has been used to explore oral protein and peptide delivery.
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