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https://www.ondrugdelivery.com/review-oral-peptide-delivery/
Figure 1: Table summarising selected oral peptide delivery technologies. MERRION’S GIPET ® TECHNOLOGY. Merrion Pharmaceuticals (Dublin, Ireland) is developing the GIPET® technology using an enteric coating (similar to Peptelligence ® and TPE technologies), in order to protect the peptide in the acidic gastric medium and ensure peptide release in the small intestine.
https://www.sciencedirect.com/science/article/pii/S1319016414000590
Oral delivery systems for proteins and peptides are still in development stages. Oral delivery, being non-invasive, is the most favored route of drug administration. This is illustrated by the fact that oral delivery represents approximately US$ 25 billion worldwide (Werle et al., 2007).Author: Abdul Muheem, Faiyaz Shakeel, Mohammad Asadullah Jahangir, Mohammed Anwar, Neha Mallick, Gaurav Kuma...
https://www.nature.com/articles/s41578-019-0156-6
Dec 24, 2019 · This Review also describes the current status of materials for oral delivery of protein and peptide drugs. New materials, beyond those that have already obtained regulatory approval, are needed to ...Author: Tyler D. Brown, Tyler D. Brown, Kathryn A. Whitehead, Samir Mitragotri, Samir Mitragotri
https://www.nature.com/articles/s41573-019-0053-0
Dec 17, 2019 · Oral delivery of peptide therapeutics could have benefits for treatment adherence, but it faces barriers related to the structural organization and physiological function of the gastrointestinal ...Author: Daniel J. Drucker
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3956587/
As oral delivery improves patient compliance, there is great interest in the development of systems that allow for the oral delivery of peptide and protein therapeutics . This review will summarize the barriers to various noninvasive delivery methods with a focus on oral and transdermal delivery.Author: Benjamin J Bruno, Geoffrey D Miller, Carol S Lim
https://www.sciencedirect.com/science/article/pii/S2211383518307305
This review summarized various multifunctional delivery systems, including lipid-based particles, polysaccharide-based particles, inorganic particles, and synthetic multifunctional particles that achieved effective oral delivery of therapeutic peptides/proteins.Author: Ying Han, Zhonggao Gao, Liqing Chen, Lin Kang, Wei Huang, Mingji Jin, Qiming Wang, You Han Bae
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2792531/
Designing oral peptide and protein delivery systems has been a persistent challenge to pharmaceutical scientists because of their several unfavorable physicochemical properties including large molecular size, susceptibility to enzymatic degradation, short plasma half-life, ion permeability, immunogenicity, and the tendency to undergo ...
https://www.pharmasalmanac.com/articles/advances-in-the-oral-delivery-of-peptides
“A review on the strategies for oral delivery of proteins and peptides and their clinical perspectives.” Saudi Pharmaceutical Journal. 24: 413–428 (2016). Chen, Liqubg et al. “Multifunctional oral delivery systems for enhanced bioavailability of therapeutic peptides/proteins.” Acta Pharmaceutica Sinica B. …
https://www.researchgate.net/publication/319122467_An_over_view_Protein_and_peptide_based_drug_delivery
In this review, the aim is to focus on the various routes and approaches for delivery of Peptide and protein drugs. ... Muheem, A review on the stra tegies for oral deliv ery of .
https://www.researchgate.net/publication/263709483_Formulation_strategies_to_improve_oral_peptide_delivery
This review provides a comprehensive up-to-date overview of the current status of oral peptide delivery with an emphasis on patented formulations that are yielding promising clinical data ...
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