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https://www.ondrugdelivery.com/review-oral-peptide-delivery/
PROTEIN ORAL DELIVERY TECHNOLOGY POD ™ POD technology developed by Oramed (Jerusalem, Israel), consists of enteric-coated capsules containing an oily suspension of the peptide drug, an enzyme inhibitor, such as soy bean trypsin inhibitor, aprotinin and an absorption enhancer such as EDTA or bile salt, in omega-3 fatty acids.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2792531/
Thus, we can achieve site-specific drug delivery by the use of mucoadhesive polymeric system. Mucoadhesive polymers are able to adhere to the mucin layer on the mucosal epithelium and thus results in the increase of oral drug bioavailability of protein and peptide drugs.
https://www.nature.com/articles/s41573-019-0053-0
Dec 17, 2019 · Oral delivery of peptide therapeutics could have benefits for treatment adherence, but it faces barriers related to the structural organization and physiological function of the gastrointestinal ...Author: Daniel J. Drucker
https://link.springer.com/content/pdf/10.1208%2Fs12249-019-1325-z.pdf
protein polypeptide drug. BARRIERS TO ORAL DELIVERY OF PROTEIN AND PEPTIDE DRUG NPS Most of the protein and peptide drugs are macromolec-ular hydrophilic, in the extreme environment of gastrointes-tinal stability, susceptible to gastric acid and pepsin degradation; at the same time, because of its hydrophilicity,Author: Shu-jun Cao, Shuo Xu, Hui-ming Wang, Yong Ling, Jiahua Dong, Rui-dong Xia, Xiang-hong Sun
https://www.sciencedirect.com/science/article/pii/S1319016414000590
Oral delivery systems for proteins and peptides are still in development stages. Oral delivery, being non-invasive, is the most favored route of drug administration. This is illustrated by the fact that oral delivery represents approximately US$ 25 billion worldwide (Werle et al., 2007).Author: Abdul Muheem, Faiyaz Shakeel, Mohammad Asadullah Jahangir, Mohammed Anwar, Neha Mallick, Gaurav Kuma...
https://www.researchgate.net/publication/40834786_Protein_and_Peptide_Drug_Delivery_Oral_Approaches
Designing means to deliver peptide and protein drugs successfully to the systemic circulation by the oral route has been a challenge to scientists in drug delivery for many years [1].
https://link.springer.com/article/10.1208/s12249-019-1325-z
May 20, 2019 · METHODS TO PROMOTE THE ORAL DELIVERY OF PROTEIN AND PEPTIDE DRUG NPs. Although it has been proved that the nanoparticles can be absorbed by the GT after oral administration, low absorption is the biggest obstacle to the development of oral nanoscale drug delivery systems. With the further research of absorption mechanism, many methods to ...Author: Shu-jun Cao, Shuo Xu, Hui-ming Wang, Yong Ling, Jiahua Dong, Rui-dong Xia, Xiang-hong Sun
https://enterisbiopharma.com/
Since its founding in 2013, Enteris BioPharma has advanced into the clinic multiple internal and external programs leveraging its Peptelligence® platform. The technology has been developed and proven effective to enable the delivery of peptide-based therapeutics and …
https://www.ddw-online.com/therapeutics/p320747-oral-peptide-therapeutics-a-holy-grail-or-quixotic-quest.html
Long hailed as the Holy Grail of drug delivery, orally-administered peptides offer vast potential but also present considerable development challenges. Challenges and opportunities in oral peptide therapeutic development. Numerous technologies are currently in development that are designed to enable the oral delivery of peptides.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3956587/
For an overview on hydrogels, see Bindu Sri et al., and for more detail on the use of hydrogels for oral peptide drug delivery, the review by Peppas et al. is helpful [103,104]. While liposome systems have potential in oral drug delivery, there is a concern with stability of the vesicles under the physiologic conditions of the GI tract .Author: Benjamin J Bruno, Geoffrey D Miller, Carol S Lim
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