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https://ois.net/punctal-plugs-for-sustained-delivery/
Nov 11, 2016 · The Evolute Punctal Plug Delivery System provides sustained ocular drug delivery that “is as good or better than what’s out there,” said Bob Butchofsky, Mati Therapeutics Inc…
https://www.ophthalmologytimes.com/ophthalmology/punctal-plug-drug-delivery-attractive-method-managing-glaucoma
Punctal plug-based delivery systems for sustained delivery of glaucoma medications represent new and versatile technology that is under development. The hope is it can help with the problem of patient compliance when managing mild-moderate glaucoma, said Marlene Moster, MD.
https://www.aao.org/annual-meeting-video/punctal-plug-delivery-systems
Although there are no FDA-approved drug delivery systems for glaucoma, 2 companies are performing clinical trials to assess the feasibility of this delivery route. Mati Therapeutics is evaluating a latanoprost-eluting punctal plug that is comfortable, but visible to the patient and doctor.
https://www.ophthalmicprofessional.com/issues/2019/may-2019/advances-in-drug-delivery-systems
May 01, 2019 · Punctal plug. Also called lacrimal plugs, these devices allow physicians to administer drugs before, during, or after surgery. In cataract surgery, the FDA recently approved dexamethasone ophthalmic insert 0.4mg (Dextenza, Ocular Therapeutix) for the treatment of pain following ophthalmic surgery (see Figure 1, page 28). The intracanalicular plug is easy to insert into the inferior punctum …
http://jpet.aspetjournals.org/content/early/2019/05/09/jpet.119.256933
Jan 01, 2019 · Ocular drug delivery has always been a challenge for ophthalmologist and drug delivery scientists due to presence of various anatomical and physiological barriers. Inimitable static and dynamic ocular barriers not only exclude the entry of xenobiotics but also discourage the active absorption of therapeutic agents.Author: Vrinda Gote, Sadia Sikder, Jeff Sicotte, Dhananjay Pal
https://www.biospace.com/article/releases/qlt-inc-initiates-phase-ii-study-of-punctal-plug-drug-delivery-system-for-glaucoma-and-ocular-hypertension-/
Mar 31, 2008 · This study is a phase II, randomized, masked, parallel-group study of safety and preliminary efficacy of a punctal plug drug delivery system involving up to 60 patients with primary open-angle glaucoma or ocular hypertension. The punctal plug drug delivery system in this study consists of three different concentrations of latanoprost, a ...
https://www.sciencedirect.com/science/article/pii/S1359644615000641
Punctal plugs (PPs) are miniature medical devices that are used to block puncta to treat dry eye syndrome. PPs are currently been investigated as sustained-release drug delivery devices. Sustained-release PPs can be used to treat a range of anterior segment eye diseases.Author: Venkata K. Yellepeddi, Venkata K. Yellepeddi, Ravi Sheshala, Hannah McMillan, Chirag Gujral, David J...
https://www.medline.com/product/Parasol-Punctal-Occluder-Systems-by-Wilson-Ophthalmic/Z05-PF140972
Parasol Punctal Occluder Systems by Wilson Ophthalmic Punctal occluder designed for simple sizing, easy insertion and retention Preloaded onto high-quality, disposable insertion instrument
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3051398/
Sep 01, 2010 · Generally, a punctal plug drug delivery system is coated with a material that is impermeable to the drug and tear fluid on all sides except the head portion, through which the drug is released into the tear film. The release of the drug from a punctal plug is controlled by drug diffusion from the polymeric core to the tear fluid.Author: Uday B Kompella, Rajendra S Kadam, Vincent Hl Lee
https://www.aao.org/eyenet/article/novel-approaches-to-drug-delivery-2
Punctal Plugs. Dr. Cantor said that punctal plugs are “very promising” as a way to deliver glaucoma drugs. The plugs are inserted into the tear ducts, where they’ll stay for at least two to three months. “In theory, it’s a very elegant, simple approach to medical treatment that removes the compliance burden.” Dr. Mitra agreed.
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