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https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2895432/
May 01, 2010 · Ocular drug delivery has been a major challenge to pharmacologists and drug delivery scientists due to its unique anatomy and physiology. Static barriers (different layers of cornea, sclera, and retina including blood aqueous and blood–retinal barriers), dynamic barriers (choroidal and conjunctival blood flow, lymphatic clearance, and tear dilution), and efflux pumps in conjunction pose a ...Author: Ripal Gaudana, Hari Krishna Ananthula, Ashwin Parenky, Ashim K. Mitra
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5995646/
Feb 15, 2018 · 5. Routes of protein and peptide delivery to ocular tissues. Challenges to ocular delivery of biopharmaceuticals are noteworthy and considerable opportunities remain to be optimized for delivery approaches, formulation and processing conditions for each peptide and protein based therapeutics.Author: Abhirup Mandal, Dhananjay Pal, Vibhuti Agrahari, Hoang My Trinh, Mary Joseph, Ashim K. Mitra
https://www.sciencedirect.com/science/article/pii/B9780123849359100057
5.1. Introduction. Protein and peptide delivery via the ocular route is an interesting but delicate approach for pharmaceutical technology. A good understanding of the physiological parameters of the eye is necessary before designing an ocular product.Author: Suresh P. Vyas, Rishi Paliwal, Shivani Rai Paliwal
https://www.semanticscholar.org/paper/Ocular-delivery-of-proteins-and-peptides%3A-and-novel-Mandal-Pal/2476b2b8e2ea396737243c7767c7c21f24a20bd0
Abstract The impact of proteins and peptides on the treatment of various conditions including ocular diseases over the past few decades has been advanced by substantial breakthroughs in structural biochemistry, genetic engineering, formulation and delivery approaches. Formulation and delivery of proteins and peptides, such as monoclonal antibodies, aptamers, recombinant proteins and peptides ...
https://d2cax41o7ahm5l.cloudfront.net/cs/speaker-ppts/richard-addo-union-university-usa.pptx
Strategies for the ocular delivery of proteins/peptides. Prodrugs. Change physicochemical properties of a drug to improve permeation across cornea and enhance bioavailability. First prodrug for ocular delivery: Dipivefrin, prodrug of epinephrine used to treat glaucoma. …
https://www.researchgate.net/publication/322468712_Ocular_delivery_of_proteins_and_peptides_Challenges_and_novel_formulation_approaches
Formulation and delivery of proteins and peptides, such as monoclonal antibodies, aptamers, recombinant proteins and peptides to ocular tissues poses significant challenges owing to their large ...
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