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https://www.sciencedirect.com/science/article/pii/S0378517312003249
Oral protein/peptide delivery strategies for are mainly based on systems that are designed to protect these therapeutics against enzymatic degradation and enable the absorption of these drugs across the intestinal epithelial mucosal layer into the blood stream.Author: M.R. Rekha, Chandra P. Sharma
https://www.ncbi.nlm.nih.gov/pubmed/22503954
Jan 02, 2013 · Oral route is the most widely accepted means of administration. However it is not feasible for direct delivery of peptide and protein drugs. To overcome the gastro-intestinal barriers various types of formulations such as polymeric micro/nanoparticles, liposomes, etc. are investigated.Author: M.R. Rekha, Chandra P. Sharma
https://www.researchgate.net/publication/224037749_Oral_delivery_of_therapeutic_proteinpeptide_for_diabetes_-_Future_perspectives
A major advantage of diabetes nanomedicine geared towards oral delivery is the enhanced bioavailability of these drugs, whereas direct delivery of free peptides and protein drugs through the gastrointestinal track is accompanied by low bioavailability due to the gastro-intestinal barriers [198][199][200][201].
https://www.nature.com/articles/s41578-019-0156-6
Dec 24, 2019 · Although oral delivery works well for small-molecule drugs, oral delivery of macromolecules (particularly proteins and peptides) has been limited by acidic conditions in the stomach and low...Author: Tyler D. Brown, Tyler D. Brown, Kathryn A. Whitehead, Samir Mitragotri, Samir Mitragotri
https://www.worldhealth.net/news/i20-therapeutics-wants-replace-syringe-pill-diabetes/
2 days ago · Encapsulating complex drugs with an ionic liquid was found to enable the oral delivery of large proteins and peptides such as insulin past the mucus barrier and walls of the intestine …
https://www.sciencedirect.com/science/article/pii/S0168365917308179
Rats were divided into two groups for oral delivery of the gene complex: one group was administered pβ-SP-GLP-1 (pGLP1) only (n = 3), while the other group was administered the HTCA-GLP1 gene complex (n = 5). Rats were fasted overnight (12h) before oral gavage delivery of 100 μg of pGLP1 or HTCA-GLP1.Author: Nurunnabi, Nurunnabi, Seung Ah Lee, Vishnu Revuri, Yong Hwa Hwang, Sung Hun Kang, Minhyung Lee, Sung...
https://www.sciencedirect.com/science/article/pii/S1319016414000590
Oral delivery systems for proteins and peptides are still in development stages. Oral delivery, being non-invasive, is the most favored route of drug administration. This is illustrated by the fact that oral delivery represents approximately US$ 25 billion worldwide (Werle et al., 2007).Author: Abdul Muheem, Faiyaz Shakeel, Mohammad Asadullah Jahangir, Mohammed Anwar, Neha Mallick, Gaurav Kuma...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4908063/
Jun 16, 2014 · Eli-Lily is still developing AI-401 for the oral delivery of proteins (recombinant product of human insulin). Besides Oral-Lyn and HIM2, AI-401 is used for the prevention and treatment of Type-1 diabetes. This technique uses the concept of oral-tolerance therapy.Author: Abdul Muheem, Faiyaz Shakeel, Mohammad Asadullah Jahangir, Mohammed Anwar, Neha Mallick, Gaurav Kuma...
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