Oral Delivery Of Therapeutic Proteins

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A review on the strategies for oral delivery of proteins ...

    https://www.sciencedirect.com/science/article/pii/S1319016414000590
    However, the major glitches in the optimal utilization of therapeutic proteins and peptides by the oral route are their extensive hepatic first-pass metabolism, degradation in the gastrointestinal tract (presence of enzymes and pH-dependent factors), large molecular size and poor permeation.Author: Abdul Muheem, Faiyaz Shakeel, Mohammad Asadullah Jahangir, Mohammed Anwar, Neha Mallick, Gaurav Kuma...

Oral delivery of therapeutic proteins and peptides: a ...

    https://www.ncbi.nlm.nih.gov/pubmed/23869787
    Despite extensive research efforts, oral delivery of therapeutic peptide or protein is still a challenge for pharmaceutical industries and researchers. Number of factors including high proteolytic activity and low pH conditions of gastrointestinal tract act as major...Author: Sonal Gupta, Arushi Jain, Mainak Chakraborty, Jasjeet K Sahni, Javed Ali, Shweta Dang

Oral delivery of therapeutic proteins and peptides: a ...

    https://www.tandfonline.com/doi/abs/10.3109/10717544.2013.819611
    Jul 17, 2018 · Despite extensive research efforts, oral delivery of therapeutic peptide or protein is still a challenge for pharmaceutical industries and researchers. Number of factors including high proteolytic activity and low pH conditions of gastrointestinal tract act as major barriers in the successful delivery of intact protein/peptide to the targeted site.Author: Sonal Gupta, Arushi Jain, Mainak Chakraborty, Jasjeet K Sahni, Javed Ali, Shweta Dang

Orally Delivered Proteins - Protalix Biotherapeutics

    http://protalix.com/technology/orally-delivered-proteins/
    Oral delivery of protein therapies produced through the ProCellEx ® platform can be made possible due to the unique cellulose wall of plant cells that makes them resistant to degradation when passing through the digestive tract. The plant cell can serve as a natural vehicle for oral administration.

Challenges for the oral delivery of macromolecules ...

    https://www.nature.com/articles/nrd1067
    Apr 01, 2003 · In particular, the commercial-scale production of high-purity recombinant proteins has resulted in important additions to treatment options for many large therapeutic areas. In addition to ...Author: Michael Goldberg, Isabel Gomez-Orellana

Oral delivery of peptides/proteins Scanaktier.se

    https://www.scanaktier.se/corporate_news/press/1464504-oral-delivery-of-peptides-proteins
    Oral delivery of peptides/proteins. Oral delivery of peptides/proteins 24 november 2010 ...

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