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https://www.researchgate.net/publication/11947879_Oral_Delivery_of_Taxanes
Oral treatment with cytotoxic agents is to be preferred as this administration route is convenient to patients, reduces administration costs and facilitates the use of more chronic treatment...
https://cancerres.aacrjournals.org/content/60/4/842
The oral bioavailability of paclitaxel in mice has been reported by van Asperen et al. to be less than 10%, but it increased dramatically when the oral paclitaxel was coadministered with P-gp inhibitors such as a cyclosporin A or its analogue SDZ PSC833, thus, suggesting the possibility of investigating the combination of oral taxanes with P-gp ...
https://www.researchgate.net/publication/26881025_Nanovehicles_for_enhanced_oral_delivery_of_taxanes
Nanovehicles for enhanced oral delivery of taxanes Article in Journal of Controlled Release 140(2):77-8 · October 2009 with 11 Reads How we measure 'reads'
https://www.onclive.com/peer-exchange/unmet-needs-mbc/tesetaxel-an-oral-taxane-for-hr-positive-mbc
Andrew D. Seidman, MD, and Joyce A. O’Shaughnessy, MD, review the emergence of tesetaxel, an oral taxane that may optimize the delivery of chemotherapy to patients with hormone receptor ...
https://www.hindawi.com/journals/bmri/2013/150478/
The aim of this study was to evaluate a nanoparticulate system with mucoadhesion properties composed of a core of polymethyl methacrylate surrounded by a shell of thiolated chitosan (Ch-GSH-pMMA) for enhancing oral bioavailability of docetaxel (DTX), an anticancer drug. DTX-loaded nanoparticles were prepared by emulsion polymerization method using cerium ammonium nitrate as an initiator ...
https://www.deepdyve.com/lp/elsevier/oral-delivery-of-paclitaxel-nanocrystal-pnc-with-a-dual-pgp-cyp3a4-44DfpIV2GE
Sep 10, 2014 · Read "Oral delivery of paclitaxel nanocrystal (PNC) with a dual Pgp-CYP3A4 inhibitor: Preparation, characterization and antitumor activity, International Journal of Pharmaceutics" on DeepDyve, the largest online rental service for scholarly research with thousands of academic publications available at your fingertips.
https://dspace.library.uu.nl/bitstream/handle/1874/330/full.pdf;sequence=1
for investigation of the feasibility of oral administration of taxanes in patients. In the clinic it was first started with a proof of concept study of orally administered paclitaxel in combination with cyclosporin A. Co-administration of cyclosporin A resulted in a significant increase in …
https://www.nature.com/articles/s41598-020-60184-2
In an attempt to improve the oral bioavailability of taxanes, a series of new analogues were synthesized and tested in a panel of human tumor cell lines and cellular permeability assays. Compounds ...
https://www.fbcoverup.com/docs/library/2016-06-09-Nanoparticles-for-oral-delivery-design-evaluation-and-state-of-the-art-funded-by-NIH-Johns-Hopkins-Burroughs-Wellcome-Hanes-Date-Ensign-NIH-Jun-09-2016.pdf
Nanoparticles for oral delivery: design, evaluation and state-of-the-art Abhijit A. Date1,2, Justin Hanes1,2,3,4, and Laura M. Ensign1,2,3,* 1The Center for Nanomedicine, The Wilmer Eye Institute, Johns Hopkins University School of Medicine, 400 N Broadway, Baltimore MD 21231, USA 2Department of Ophthalmology, The Wilmer Eye Institute, Johns Hopkins University School of
http://www.eurekaselect.com/openurl/content.php?genre=article&issn=1381-6128&volume=22&issue=33&spage=5127
Abstract: Chemotherapy is one of the most frequently employed and reliable treatment options for the management of a variety of cancers. Taxanes (paclitaxel, docetaxel and cabazitaxel) are frequently prescribed to treat breast cancer, hormone refractory prostate …
http://www.nature.com/articles/bjc2014222
Apr 29, 2014 · The oral availability of taxanes can be enhanced by co-administration with oral elacridar and ritonavir, without increasing the brain penetration of the taxanes. ... (anhydride) nanoparticles for ...
https://pubs.acs.org/doi/10.1021/bm400406x
May 30, 2013 · We describe the development and evaluation of a hybrid lipopolymeric system comprising carboxymethyl chitosan (CMC), covalently tethered to phosphatidylethanolamine units on the surface of lipid nanovesicles, for oral delivery of paclitaxel. The bioploymer is intended to act as a blanket, thereby shielding the drug from harsh gastrointestinal conditions, whereas the lipid nanovesicle ensures ...
http://www.mrl.ucsb.edu/~safinya/papers/Reactions%20to%20Taxane%20drugs%20P1.pdf
Re-visiting Hypersensitivity Reactions to Taxanes: A Comprehensive Review Matthieu Picard & Mariana C. Castells # Springer Science+Business Media New York 2014 Abstract Taxanes (a class of chemotherapeutic agents) are an important cause of hypersensitivity reactions (HSRs) in cancer patients. During the last decade, the
https://www.hindawi.com/journals/bmri/2014/984756/
3.2. Preparation of Solid-Nanoemulsion Preconcentrate. The nanoemulsion preconcentrate (formulation S 4) was selected to prepare PAC loaded solid-nanoemulsion preconcentrate with the aid of POE 4000 as a carrier.It was found that when the isotropic mixture of formulation S 4 was dispersed in molten POE 4000 by fusion method and then cooled to room temperature, a consistent solid matrix was ...
https://www.pnas.org/content/pnas/110/43/17498.full.pdf
Oral delivery system prolongs blood circulation of docetaxel nanocapsules via lymphatic absorption Suha Attili-Qadria, Nour Karraa, Alina Nemirovskia, Ouri Schwoba, Yeshayahu Talmonb, Taher Nassara,1, and Simon Benitaa,1,2 aInstitute for Drug Research, School of Pharmacy, Faculty of Medicine, The Hebrew University of Jerusalem, Jerusalem 91120, Israel; and bDepartment of
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