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http://www.pmlive.com/pharma_intelligence/oral_biologics_delivery_still_elusive_908436
Oral biologics delivery still elusive. The search for a better delivery method for peptide, protein and antibody drugs Despite decades of effort, oral delivery of peptide, protein and antibody drugs remains a major pharmaceutical challenge, with only a handful of products on the market. ... For really large molecules like antibodies the ...
https://link.springer.com/article/10.2165%2F00003088-199732040-00004
Oct 25, 2012 · Future opportunities for research include the design of oral dosage forms of antibodies which resist proteolysis and can deliver a greater fraction of immunoreactive antibody locally in the gastrointestinal tract for the treatment of infections or perhaps even to allow the absorption of antibodies for the treatment or prevention of systemic ...Author: Raymond M. Reilly, Rommel Domingo, Jasbir Sandhu
https://www.ncbi.nlm.nih.gov/pubmed/29973504
Jul 04, 2018 · Overview of Antibody Drug Delivery. Awwad S(1)(2), Angkawinitwong U(3). ... Monoclonal antibodies (mAbs) are one of the most important classes of therapeutic proteins, which are used to treat a wide number of diseases (e.g., oncology, inflammation and autoimmune diseases). Monoclonal antibody technologies are continuing to evolve to develop ...Author: Sahar Awwad, Ukrit Angkawinitwong
http://www.vhsquared.com/wp-content/uploads/2018/11/Oral-delivery-of-the-anti-tumor-necrosis-factor-domain-antibody-V565-results-in-high-intestinal-and-fecal-concentrations-with-minimal-systemic.pdf
Oral delivery of the anti-tumor necrosis factor a domain antibody, V565, results ... These monoclonal antibodies (mAbs) must be administered parenterally requiring either a hos-pital visit or multiple injections that are inconvenient for both patients and medical practitioners, and can be painful. There areFile Size: 1MB
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6690423/
We did confirm that, in contrast to parenteral administration of OKT3, oral delivery was not associated with cytokine release syndrome, T-cell depletion, or generation of human anti-mouse antibodies in subjects with UC. 8–11 The side effect profile in patients with active UC was similar to that seen in other human studies. 19,28,29 These ...Author: Elisa K Boden, Elisa K Boden, James B Canavan, James B Canavan, James B Canavan, Christopher J Moran...
https://www.nih.gov/news-events/news-releases/drug-delivery-technology-leads-sustained-hiv-antibody-production-nih-study
Mar 09, 2020 · “We hope that further development of this technology will yield a drug-delivery strategy applicable to a broad range of infectious diseases.” Administration of monoclonal antibody-based therapies sometimes results in a person’s immune system developing antibodies against the therapy.
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