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https://www.sciencedirect.com/book/9781907568473/oral-delivery-of-insulin
Abstract. One of the greater challenges faced by oral delivery of insulin is the reduced bioavailability. Among the different types of carrier-based delivery systems currently being pursued for oral insulin delivery, biodegradable polymeric nanoparticles have received considerable attention due to their versatility and wide range of properties.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3737653/
Mar 01, 2013 · Oral insulin delivery has been an interesting and promising research field that promises to revolutionize the way diabetes mellitus is treated. Several studies have achieved some positive results, and some delivery systems are in advanced stages of development.Author: Pedro Fonte, Francisca Araújo, Salette Reis, Bruno Sarmento
https://www.pnas.org/content/115/28/7296
Jul 10, 2018 · Insulin is currently available as an injectable formulation, but an oral product would enjoy higher patient compliance and would significantly improve the quality of life of diabetic patients worldwide. However, oral delivery of proteins such as insulin is challenging due to various gastrointestinal barriers to oral absorption of macromolecules.Author: Amrita Banerjee, Kelly Ibsen, Kelly Ibsen, Tyler Brown, Renwei Chen, Christian Agatemor, Samir Mitra...
https://www.diabetesnet.com/about-diabetes/insulin/insulin-delivery/oral-insulin-delivery/
An oral tablet insulin product would do away with the above-cited limitations of injectable insulin, and inhaled insulin, in addition to the fact that oral delivery would have high patient compliance. Below are some companies currently trying to make this delivery process possible.
https://www.outsourcing-pharma.com/Article/2019/10/15/Novo-Nordisk-and-MIT-on-oral-delivery-of-insulin
Oct 15, 2019 · The research is funded by Novo Nordisk and the US National Institute of Health (NIH). Commenting on the approach, Rose Joachim, an immunology analyst at GlobalData, said that “oral delivery of biologics has been long complicated by the poor absorption of the larger macromolecules through the intestinal wall.” “It is possible the technology will soon be seen in Novo Nordisk’s pipeline ...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4787057/
The oral route of insulin administration may be the most patient-friendly way of taking insulin and it could more closely mimic physiological insulin delivery (more portal insulin concentration than peripheral). However, the challenges in making oral insulin include: Inactivation by proteolytic enzymes in the GI tract and low permeability ...
https://medicalxpress.com/news/2020-04-toss-syringe-oral-delivery-drugs.html
1 day ago · In a 2018 publication in the Proceedings of the National Academy of Sciences, Mitragotri's lab demonstrated the successful oral delivery of insulin, in animal models, using ionic liquids. "We ...
https://www.intechopen.com/books/recent-advances-in-novel-drug-carrier-systems/oral-delivery-of-insulin-novel-approaches
The improved oral delivery of insulin from a microemulsion system was also demonstrated by others . A stable self-emulsifying formulation for the oral delivery of insulin was developed by Ma et al. . It is composed of two non-ionic surfactants (polyethylene glycol-8-glycol octanoate/decanoate and polyglycerol-3 oleate).Author: Amani M. Elsayed
https://www.oramed.com/first-oral-insulin-for-diabetics-steps-towards-fda-approval/
Oramed Pharmaceuticals Inc. (NASDAQ/TASE: ORMP), a clinical-stage pharmaceutical company focused on the development of oral drug delivery systems, is working to bring the first oral insulin product to market, providing a more convenient, effective and safer method for delivering insulin therapy.
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