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https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3737653/
Mar 01, 2013 · However, the oral delivery of insulin remains a challenge because its oral absorption is limited. The main barriers faced by insulin in the gastrointestinal tract are degradation by proteolytic enzymes and lack of transport across the intestinal epithelium.Author: Pedro Fonte, Francisca Araújo, Salette Reis, Bruno Sarmento
https://www.sciencedirect.com/book/9781907568473/oral-delivery-of-insulin
Current means of therapy for Diabetes Mellitus do not mimic the normal physiological pattern of insulin release. Oral delivery is the preferred route of administration due to its non-invasive nature. Oral delivery of insulin presents an overview of Diabetes Mellitus, and discusses the strategies and techniques adopted for oral delivery of insulin.
https://www.elsevier.com/books/oral-delivery-of-insulin/sonia/978-1-907568-47-3
Oral delivery of insulin presents an overview of Diabetes Mellitus, and discusses the strategies and techniques adopted for oral delivery of insulin. This title begins with an introductory chapter on symptoms, complications and therapy for Diabetes Mellitus.
https://onlinelibrary.wiley.com/doi/pdf/10.1111/jphp.12852
insulin use, basic challenges in oral delivery of insulin, some strategies trialled and finally mitogenic concerns of oral insulin. Insulin-related physiology After it is secreted from pancreatic b-cells into the portal vein, insulin is directly transferred to the liver where it isAuthor: Ahmed Gedawy, Jorge Martinez, Hani Al‐Salami, Crispin R. Dass
https://www.pnas.org/content/115/28/7296
Jul 10, 2018 · Insulin is currently available as an injectable formulation, but an oral product would enjoy higher patient compliance and would significantly improve the quality of life of diabetic patients worldwide. However, oral delivery of proteins such as insulin is challenging due to various gastrointestinal barriers to oral absorption of macromolecules.Author: Amrita Banerjee, Kelly Ibsen, Kelly Ibsen, Tyler Brown, Renwei Chen, Christian Agatemor, Samir Mitra...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4383223/
Insulin is the drug therapy for patients with insulin-dependent diabetes mellitus. A number of attempts have been made in the past to overcome the problems associated with the oral delivery of insulin, but with little success. Orally administered insulin has encountered with many difficulties such as rapid degradation and poor intestinal ...Author: Sampath Malathi, Perumal Nandhakumar, Velayudham Pandiyan, Thomas J Webster, Sengottuvelan Balasubra...
https://pubag.nal.usda.gov/catalog/6841068
To improve the quality of life of diabetic patients, oral delivery of insulin would be better than subcutaneous injection, and the encapsulation of insulin for its oral delivery is a promising alternative one. In this study, we prepared an oral insulin delivery system using thiolated chitosan nanoparticles (TCNPs) loaded with insulin (Ins) and ...
https://science.sciencemag.org/content/363/6427/611.full
Feb 08, 2019 · Oral delivery is the simplest and least invasive way to deliver many pharmaceuticals, but many drugs and medications, including insulin, cannot survive passage through the stomach or the gastrointestinal tract.Author: Alex Abramson, Ester Caffarel-Salvador, Minsoo Khang, David Dellal, David Silverstein, Yuan Gao, Mor...
https://www.scilit.net/article/99c8db78d487be6b2d7d5b8af2dd74c7
These results indicate the possible oral delivery of insulin using this combination of polymers. In this study, different ratios of mucin-grafted polyethylene-glycol-based microparticles were prepared and evaluated both in vitro and in vivo as carriers for the oral delivery of insulin.
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