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https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2895432/
May 01, 2010 · Ocular drug delivery has been a major challenge to pharmacologists and drug delivery scientists due to its unique anatomy and physiology. Static barriers (different layers of cornea, sclera, and retina including blood aqueous and blood–retinal barriers), dynamic barriers (choroidal and conjunctival blood flow, lymphatic clearance, and tear dilution), and efflux pumps in conjunction pose a ...Author: Ripal Gaudana, Hari Krishna Ananthula, Ashwin Parenky, Ashim K. Mitra
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4289909/
The major challenge faced by today’s pharmacologist and formulation scientist is ocular drug delivery. Topical eye drop is the most convenient and patient compliant route of drug administration, especially for the treatment of anterior segment diseases.Author: Ashaben Patel, Kishore Cholkar, Vibhuti Agrahari, Ashim K Mitra
https://pharm.ucsf.edu/desai/research/ocular-drug-delivery
A drug delivery device capable of sustained release of biological therapeutics over several months can maintain effective therapeutic concentrations and reduce the number of injections, significantly improving ocular therapies. One attractive platform for continuous delivery of antibody-based therapeutics is the use of nanoporous materials.
http://jpet.aspetjournals.org/content/early/2019/05/09/jpet.119.256933
Jan 01, 2019 · Ocular drug delivery has always been a challenge for ophthalmologist and drug delivery scientists due to presence of various anatomical and physiological barriers. Inimitable static and dynamic ocular barriers not only exclude the entry of xenobiotics but also discourage the active absorption of therapeutic agents. An ideal drug delivery system should be designed to enhance drug ...Author: Vrinda Gote, Sadia Sikder, Jeff Sicotte, Dhananjay Pal
https://www.arvo.org/globalassets/annual-meeting/program/education-courses/2020-agenda---ocular-drug-delivery.pdf
Ocular drug delivery is an evolving field featuring cutting-edge advances in devices, formulations, and paradigms for design and characterization. This course will draw upon experts in the various disciplines of the field in order to instruct
https://www.researchgate.net/publication/235924442_OCULAR_DRUG_DELIVERY_A_REVIEW
OCULAR DRUG DELIVERY: A REVIEW ... In conclusion, polymeric micelle prepared with solid dispersion using Soluplus® can be a potential nanomedicine for ocular delivery of …
https://www.healio.com/ophthalmology/cornea-external-disease/news/print/ocular-surgery-news/%7Bd69fee03-15c5-4fbd-a090-4f8a5b294c17%7D/understanding-topical-ophthalmic-drug-delivery-how-much-gets-in
Ocular Surgery News In understanding how much of an artificial tear or a prescription eye drop actually reaches its target tissue, it is helpful to appreciate the significant obstacles to drug ...
http://samples.jbpub.com/9781284025682/9781449674250_CH10.pdf
Ocular Drug Delivery AswAni Dutt VADlApuDi, Kishore CholKAr, supriyA reDDy DAsAri, AnD Ashim K. mitrA CHAPTER OBJECTIVES Upon completing this chapter, the reader should be able to Describe the anatomy and physiology of the eye. Understand the importance of various routes of drug administration to the eye. Describe various barriers to ocular drug delivery and constraints with
https://www.researchgate.net/publication/225897418_OCULAR_DRUG_DELIVERY_SYSTEM_-_A_REVIEW
A successful design of a drug delivery system, therefore, requires an integrated knowledge of the drug molecule and the constraints offered by the ocular route of administration [3].
https://www.pharmatutor.org/articles/review-on-ocular-drug-delivery
2. To provide sustained and controlled drug delivery. 3. To increase the ocular bioavailability of drug by increasing the corneal contact time. This can be achieved by effective adherence to corneal surface. 4. To provide targeting within the ocular globe so as to prevent the loss to other ocular tissues. 5.
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