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https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2700785/
Transdermal delivery has a variety of advantages compared with the oral route. In particular, it is used when there is a significant first-pass effect of the liver that can prematurely metabolize drugs. Transdermal delivery also has advantages over hypodermic injections, which are painful, generate ...Author: Mark R Prausnitz, Robert Langer
https://www.sciencedirect.com/science/article/pii/S0169409X17301801
Although the betterment of transdermal delivery so far has focused on maximizing the delivery efficiency, transdermal drug delivery is yet to see another breakthrough by adopting a paradigm shift towards personalized therapy , , .Furthermore, transdermal delivery is set to adopt an advanced paradigm of device-assisted personalized therapy where the precise control of the amount and duration of ...Author: Hyunjae Lee, Changyeong Song, Seungmin Baik, Dokyoon Kim, Taeghwan Hyeon, Dae-Hyeong Kim
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4695828/
Oct 22, 2015 · 2. Transdermal Drug Delivery (TDD) TDD is a painless method of delivering drugs systemically by applying a drug formulation onto intact and healthy skin [2,5].The drug initially penetrates through the stratum corneum and then passes through the deeper epidermis and dermis without drug accumulation in the dermal layer.Author: Ahlam Zaid Alkilani, Maelíosa T.C. McCrudden, Ryan F. Donnelly
https://www.fdanews.com/ext/resources/files/2019/11-20-19-TDSdraftguidance.pdf?1574288455
Topically administered liquid and semi-solid drug products without a carrier device (e.g., gels, creams, lotions, foams, ointments, or sprays) are not considered to be TDS and are not covered by this guidance, even though they can be formulated to provide local, or in some cases, transdermal delivery of the drug.
https://www.ondrugdelivery.com/wp-content/uploads/2017/05/1060_GF_ONdrgDelivery_Issue-56_-transdermal_MR.pdf
devices or require a long delivery time. With 3M Hollow Microstructured Transdermal System, it is possible to deliver more viscous solutions, up to 25 centipoise (cp), with options for delivery of up to 80 cp. The drug product formulation must also be chemically compatible with the device. This is essential, especially upon stability storage.
https://www.fda.gov/industry/generic-drug-user-fee-amendments/fys-2013-2017-gdufa-science-and-research-report-transdermal-drug-products
In vitro–in vivo correlations for nicotine transdermal delivery systems evaluated by both in vitro skin permeation (IVPT) and in vivo serum pharmacokinetics under the influence of transient heat ...
https://advances.sciencemag.org/content/3/3/e1601314.full
Mar 01, 2017 · Fig. 1 Wearable/disposable sweat monitoring device and microneedle-based transdermal drug delivery module. (A) Optical camera image (top; dotted line, edges of the patch) and schematic (bottom) of the wearable sweat monitoring patch.A porous sweat-uptake layer is placed on a Nafion layer and sensors. (B) Optical camera image (top) and schematic (bottom) of the disposable sweat …Author: Hyunjae Lee, Changyeong Song, Yong Seok Hong, Min Sung Kim, Hye Rim Cho, Taegyu Kang, Kwangsoo Shin,...
https://www.medicaldesignandoutsourcing.com/microneedle-technology-transdermal-drug-delivery/
Jun 23, 2016 · A subset of transdermal drug delivery, microneedle technology using liquid silicone rubber (LSR), provides stronger, smaller polymers that are more stable and can last longer through multiple uses. This is helping to drive the growth of the transdermal drug delivery market. We look now at manufacturing and engineering progression as part of this growth.
https://www.ondrugdelivery.com/transdermal-delivery-device-design/
The product development process for a transdermal drug delivery (TDD) system is multidisciplinary in nature. Much of the scientific literature in the field of transdermal delivery pertains to skin permeation and methods of skin penetration enhancement because these are the fundamental issues that must be addressed for any transdermal drug ...
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