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https://www.sciencedirect.com/science/article/pii/S0168365912002490
The concept to use genes as drugs for human therapy, originally conceived around 1970, was the logical consequence of at least two major advances occurring at the time, namely the exponential growth in the knowledge of human gene function and the impact of their mutations, and the progressive development of more effective technologies for DNA delivery into mammalian cells . Initially, gene therapy …Author: Mauro Giacca, Serena Zacchigna
https://www.sciencedirect.com/science/article/abs/pii/S0168365912002490
So far, the vast majority of gene therapy clinical trials have exploited viral vectors as very efficient nucleic acid delivery vehicles both in vivo and ex vivo.
https://www.researchgate.net/publication/224768564_Virus-mediated_gene_delivery_for_human_gene_therapy
Request PDF Virus-mediated gene delivery for human gene therapy After over 20 years from the first application of gene transfer in humans, gene therapy is now a mature discipline, which has ...
https://courses.helsinki.fi/sites/default/files/course-material/4512177/16%20Virus-mediated%20gene%20delivery%20for%20human%20gene%20therapy.pdf
Virus-mediated gene delivery for human gene therapy Mauro Giacca ⁎ , Serena Zacchigna Molecular Medicine Laboratory, International Centre for Genetic Engineering and Biotechnology (ICGEB), Trieste, Italy
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3507026/
Jul 06, 2012 · The ultimate goal of gene therapy is single administration of an appropriate material to replace a defective or missing gene. [ 2] The first human gene transfer was utilized in 1989 on tumor-infiltrating lymphocytes [ 3, 4] and the first gene therapy was done on ADA gene for treatment of patients with SCID...
https://www.liebertpub.com/doi/10.1089/hum.2019.127
Dec 16, 2019 · There are many kidney diseases that might be addressed by gene therapy. However, gene delivery to kidney cells is inefficient. This is due, in part, to the fact that the kidney excludes molecules above 50 kDa and that most gene delivery vectors are megaDaltons in mass.Author: Jeffrey D. Rubin, Tien V. Nguyen, Kari L. Allen, Katayoun Ayasoufi, Michael A. Barry
https://www.ncbi.nlm.nih.gov/pubmed/32042148
Feb 10, 2020 · Adeno-associated virus (AAV) vector-mediated gene delivery was recently approved for the treatment of inherited blindness and spinal muscular atrophy, and long-term therapeutic effects have been achieved for other rare diseases, including haemophilia and Duchenne muscular dystrophy.Author: Chengwen Li, R. Jude Samulski
https://www.nature.com/articles/3302588
However, the gene delivery efficiency of human serotype 5 recombinant adenoviruses (Ad5) in cancer gene therapy clinical trials to date has been limited, mainly due to the paucity of the primary ...Author: M. A. Stoff-Khalili, M. A. Stoff-Khalili, A. A. Rivera, J. N. Glasgow, L. P. Le, A. Stoff, M. Everts...
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