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https://www.ncbi.nlm.nih.gov/pubmed/11500256
Novel mechanisms and devices to enable successful transdermal drug delivery. Barry BW(1). Author information: (1)Drug Delivery Group, School of Pharmacy, University of Bradford, Bradford BD7 1DP, UK. [email protected] Optimisation of drug delivery through human skin is important in …Author: B.W Barry
https://www.sciencedirect.com/science/article/pii/S0928098701001671
Recently, the transdermal route has vied with oral treatment as the most successful innovative research area in drug delivery. In the USA (the most important clinical market), out of 129 drug delivery candidate products under clinical evaluation, 51 are transdermal or dermal systems; 30% of 77 candidate products in preclinical development represent such drug delivery.Author: B.W Barry
https://www.sciencedirect.com/science/article/abs/pii/S0928098701001671
Optimisation of drug delivery through human skin is important in modern therapy. This review considers drug–vehicle interactions (drug or prodrug selection, chemical potential control, ion pairs, coacervates and eutectic systems) and the role of vesicles and particles (liposomes, transfersomes, ethosomes, niosomes).Author: B.W Barry
https://www.researchgate.net/publication/11845152_Novel_Mechanisms_and_Devices_to_Enable_Successful_Transdermal_Drug_Delivery
Optimisation of drug delivery through human skin is important in modern therapy. This review considers drug-vehicle interactions (drug or prodrug selection, chemical potential control, ion pairs, coacervates and eutectic systems) and the role of vesicles and particles (liposomes, transfersomes, ethosomes, niosomes).
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2752650/
Dec 08, 2008 · Barry BW. Novel mechanisms and devices to enable successful transdermal drug delivery. Eur J Pharm Sci. 2001; 14 (2):101–14. Bashir SJ, Chew AL, et al. Physical and physiological effects of stratum corneum tape stripping. Skin Research and Technology. 2001; 7 (1):40–48.Author: Anubhav Arora, Mark R. Prausnitz, Samir Mitragotri
https://jbioleng.biomedcentral.com/articles/10.1186/s13036-017-0088-x
Dec 12, 2017 · Needle-free, painless and localized drug delivery has been a coveted technology in the area of biomedical research. We present an innovative way of trans-dermal vaccine delivery using a miniature detonation-driven shock tube device. This device utilizes~2.5 bar of in situ generated oxyhydrogen mixture to produce a strong shockwave that accelerates liquid jets to velocities of about …Author: Janardhanraj Subburaj, Akshay Datey, Jagadeesh Gopalan, Dipshikha Chakravortty
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4833371/
Elastic vesicle scaffolds have been developed and evaluated as novel topical and transdermal delivery systems, with an infrastructure consisting of hydrophobic and hydrophilic moieties together, and as a result, such scaffolds can accommodate drug molecules with a wide range of solubility.Author: Sima Singh, Harsh Vardhan, Niranjan G Kotla, Balaji Maddiboyina, Dinesh Sharma, Thomas J Webster
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1502392/
Not all drugs are easily absorbed through the skin but, for those that are or can be altered or enhanced to be so, transdermal delivery offers distinct advantages. 10 In addition to increasing convenience, transdermal delivery can change the metabolism and bioavailability of compounds and their metabolites and thus alter the therapeutic index of a particular drug. Because of the reduced frequency of administration, compliance should be enhanced with transdermal delivery.Author: Victor W Nitti
https://academic.oup.com/bjaed/article/7/5/171/535087
Oct 01, 2007 · The properties of a drug that enable good penetration through the stratum corneum can be deduced from the equation for steady-state flux. 2 When the cumulative mass of a ... it means that the device will be unsuitable for those patients with higher opioid ... Novel mechanisms and devices to enable successful transdermal drug delivery, ...Author: Lyn Margetts, Richard Sawyer
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3255417/
Mechanism of Action of the Ethosomal Drug Delivery System. A synergistic mechanism was suggested between ethanol, vesicles, and skin lipids. The enhanced delivery of actives using ethosomes over liposomes can be ascribed to an interaction between ethosomes and skin lipids. A possible mechanism for this interaction has been proposed.
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