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https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4787057/
Oral delivery systems intended for colonic release of insulin were devised according to microflora-, pH-and time-dependent strategies were well described in a review by Maroni et al. Bioavailability and pharmacological availability data are generally still far from being reliable in terms of magnitude, onset, duration and above all, consistency for this route of administration and it is under investigation.
https://link.springer.com/article/10.2165%2F00002512-200320040-00006
Aug 31, 2012 · Buccal or nasal insulin combined with absorption enhancers proved to have interesting properties. Inhaled insulin appears to be suitable for use in patients with diabetes because of its better bioavailability and a pharmacokinetic profile that mimics the time kinetics of insulin secretion …Author: Joël Belmin, Paul Valensi
https://www.webmd.com/diabetes/features/insulin-delivery
This device is about the size of a pager. You wear it on your belt or in a pocket. It delivers a steady stream of insulin to your body 24 hours a day through a needle attached to a flexible plastic tube. Whenever you eat, you press a button on the pump to give yourself an extra boost of insulin…
https://www.ncbi.nlm.nih.gov/pubmed/29792143
Therefore, the present review was aimed to overview the challenges encountered with the current insulin delivery systems and to summarize recent advancements in technology of various novel insulin delivery systems being discovered and introduced in the current market.Author: Manisha Pandey, Hira Choudhury, Cheah Xiao Yi, Chen Wei Mun, Goh Khang Phing, Guee Xin Rou, Bhalqish...
http://www.pharmtech.com/novel-approaches-oral-insulin-delivery
Jul 02, 2009 · Novel Approaches for Oral Insulin Delivery The authors review various oral drug delivery systems that have been explored to increase patient compliance for insulin. Jul 02, 2009
https://www.intechopen.com/books/recent-advances-in-novel-drug-carrier-systems/oral-delivery-of-insulin-novel-approaches
It is a nontoxic, highly water-soluble, biodegradable and biocompatible branched negatively charged polyion. A nanoparticle insulin delivery system was prepared by the polyelectrolyte complexation of oppositely charged natural polymers - dextran sulphate and chitosan in an aqueous solution.Author: Amani M. Elsayed
https://care.diabetesjournals.org/content/43/3/597
Mar 01, 2020 · The artificial pancreas is a novel technology that automates insulin pump delivery in type 1 diabetes based on glucose sensor readings and a dosing algorithm (2). Randomized trials have shown that the artificial pancreas reduces hyperglycemia and hypoglycemia compared with sensor-augmented pump therapy (3).Author: Ahmad Haidar, Ahmad Haidar, Michael A. Tsoukas, Sarah Bernier-Twardy, Jean-Francois Yale, Joanna Rut...
http://pharmrev.aspetjournals.org/content/67/3/541
Jul 01, 2015 · Delivery systems for peptides have been under development since the discovery of insulin for the treatment of diabetes. The challenge of using peptides as drugs arises from their poor bioavailability resulting from the low permeability of biological membranes and their instability.Author: Miia Kovalainen, Juha Mönkäre, Joakim Riikonen, Ullamari Pesonen, Maria Vlasova, Jarno Salonen, Vesa...
https://www.researchgate.net/publication/320345077_Oral_Insulin_Delivery_Novel_Strategies
Oral Insulin Delivery: Novel Strategies. Diabetes is a disorder related to the deficiency in the secretion or action of insulin-a peptide hormone synthesized by the β cells of islets of pancreas. Insulin is given by the subcutaneous (SC) route. Patient non-compliance is frequent with the SC route.
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