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http://jpet.aspetjournals.org/content/370/3/593
Sep 01, 2019 · Nose-to-Brain Mechanism of Delivery. For the purposes of drug delivery, the nasal cavity is divided into the respiratory area and the olfactory area, with the latter situated high up in the nares and the former closer to the nostrils (Sahin-Yilmaz and Naclerio, 2011).The nasal epithelium is well vascularized (Sahin-Yilmaz and Naclerio, 2011), and, within the olfactory area, olfactory neurons ...Author: Zian Wang, Guojun Xiong, Wai Chun Tsang, Andreas G. Schätzlein, Ijeoma F. Uchegbu
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6199953/
May 14, 2018 · The direct nose-to-brain drug delivery offers a potential strategy for the treatment of AD. The strategy is still under investigations with various successful lab scale studies and numerous challenges to reach the pharmacy counter.Author: Amit Alexander, Shailendra Saraf
https://www.mdpi.com/1999-4923/11/2/84/pdf
Nose-to-brain drug delivery is a painless, non-invasive administration route that can be used to deliver therapeutic agents into the brain by bypassing the BBB [10,14–17]. These drug administration pathways are characterized by many advantages such as increasedAuthor: Maria Cristina Bonferoni, Silvia Rossi, Giuseppina Sandri, Franca Ferrari, Elisabetta Gavini, Giovan...
https://www.omicsonline.org/open-access/nose-to-brain-drug-delivery-a-recent-update.pdf
Nose to Brain Drug Delivery: A Recent UpdateAuthor: Bappaditya Chatterjee
https://www.ncbi.nlm.nih.gov/pubmed/25039773
The delivery of drugs to the brain via the nose-to-brain route holds great promise, on the basis of preclinical research by means of drug delivery systems such as polymeric nanoparticles and clinical data related to intranasal delivery to CNS of large molecular weight biologics administered in solution, but safety issues about toxicity on nasal ...Author: Wei-Yi Ong, Suku-Maran Shalini, Luca Costantino
https://www.researchgate.net/publication/235980914_Direct_nose_to_brain_drug_delivery_via_integrated_nerve_pathways_bypassing_the_blood-brain_barrier_An_excellent_platform_for_brain_targeting
Expert opinion:Direct nose to brain drug delivery system is a practical, safe, non-invasive and convenient form of formulation strategy and could be viewed as an excellent alternative approach to ...
https://www.researchgate.net/publication/234044763_Nose_to_Brain_Targeted_Drug_Delivery_bypassing_the_Blood-Brain_Barrier_An_overview
This chapter discusses the scientific developments of nose-to-brain delivery of drugs in the past 10 years and the use of novel delivery systems and devices for optimization of the amount of drug ...
http://www.jocpr.com/articles/nose-to-brain-drug-delivery-new-perspectives-for-old-problemsan-enlightening-review.pdf
Nose to Brain Drug Delivery: New Perspectives for Old Problems -An Enlightening Review SL Jyothi, ... Factors Affecting Nose to Brain Drug Delivery The factors which affect absorption of drug through intranasal route are the physical as well as the chemical properties of the drug substance, the environment of the nose and dosage form ...
https://www.slideshare.net/ishanipandit034/brain-targeted-drug-delivery-through-nasal-route
Mar 01, 2015 · Brain Targeted Drug Delivery through Nasal Route. ... II. Nose to Brain drug delivery system : o The success of cell based therapy for neurodegenerative disorders depend on therapeutic properties of the cell type, on the method and safety of administration, on the amount of cells delivered to the site of injury and finally on the avoidence of ...
https://www.sciencedirect.com/science/article/abs/pii/S0168365918302682
Although, after all, such successful research claims, very few of the nose-to-brain drug delivery of anti-AD drugs have gained market approval due to lack of sufficient clinical evidence. Onzetra Xsail® is one such marketed preparations approved for IN delivery used for the treatment of a brain disorder; migraine.Author: Mukta Agrawal, Swarnlata Saraf, Shailendra Saraf, Sophia G. Antimisiaris, Mahavir Bhupal Chougule, S...
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