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https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6409749/
Feb 17, 2019 · Nose-to-brain drug delivery is a painless, non-invasive administration route that can be used to deliver therapeutic agents into the brain by bypassing the BBB [10,14,15,16,17].Author: Maria Cristina Bonferoni, Silvia Rossi, Giuseppina Sandri, Franca Ferrari, Elisabetta Gavini, Giovan...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6199953/
May 14, 2018 · Current research and available therapies: Nowadays, the direct nose-to-brain drug delivery appears as an innovative, convenient and effective strategy for the treatment of various brain disorders. A considerable research database (including on-going research, preclinical investigations, clinical studies and various patents) promises the potency of the IN approach for the treatment of AD and other brain disorders …Author: Amit Alexander, Shailendra Saraf
http://jpet.aspetjournals.org/content/370/3/593
Sep 01, 2019 · Nose-to-Brain Mechanism of Delivery For the purposes of drug delivery, the nasal cavity is divided into the respiratory area and the olfactory area, with the latter situated high up in the nares and the former closer to the nostrils (Sahin-Yilmaz and Naclerio, 2011).Author: Zian Wang, Guojun Xiong, Wai Chun Tsang, Andreas G. Schätzlein, Ijeoma F. Uchegbu
https://www.mdpi.com/journal/pharmaceutics/special_issues/nose_brain_delivery
In the field of nasal drug delivery, nose-to-brain delivery is among the most fascinating applications, directly targeting the central nervous system, bypassing the blood brain barrier. Its benefits include dose lowering and direct brain distribution of potent drugs, ultimately reducing systemic side effects.
https://www.sciencedirect.com/science/article/pii/S0168365918302682
In general, the nose to brain drug delivery involves the transfer of drug mainly from respiratory epithelium and olfactory region through trigeminal nerve and olfactory nerve cells. This transfer supposed to deliver the drug molecules directly to the different part of the brain including the frontal cortex, olfactory bulb, cerebrum and brain stem [ 38 , 83 ] ( Fig. 4 ).Author: Mukta Agrawal, Swarnlata Saraf, Shailendra Saraf, Sophia G. Antimisiaris, Mahavir Bhupal Chougule, S...
https://www.mdpi.com/1999-4923/11/2/84/pdf
administration of drugs using the nose-to-brain pathway allows direct drug targeting into the brain, avoiding the first-pass effect and bypassing the BBB. Through the nasal route, the drug can access the brain directly along the trigeminal and olfactory nerves, …Author: Maria Cristina Bonferoni, Silvia Rossi, Giuseppina Sandri, Franca Ferrari, Elisabetta Gavini, Giovan...
http://www.eurekaselect.com/123425/article
The delivery of drugs to the brain via the nose-to-brain route holds great promise, on the basis of preclinical research by means of drug delivery systems such as polymeric nanoparticles and clinical data related to intranasal delivery to CNS of large molecular weight biologics administered in solution,...
http://www.jocpr.com/articles/nose-to-brain-drug-delivery-new-perspectives-for-old-problemsan-enlightening-review.pdf
For the delivery of drugs from nose to brain, the low dose is required. This route of administration avoids first pass effect, onset of action is rapid, bioavailability is more and it has no degradation in GIT or toxicity in lungs and it does not cause pain.
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