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https://pubs.acs.org/doi/10.1021/cr800409e
Dec 03, 2008 · Cationic Amino Acid Based Lipids as Effective Nonviral Gene Delivery Vectors for Primary Cultured Neurons. ACS Chemical Neuroscience 2013, 4 (12) , 1514-1519. DOI: 10.1021/cn400036j. Yang Yang, Ying-Ming Zhang, Yong Chen, Jia-Tong Chen, and Yu Liu .Author: Meredith A. Mintzer, Eric E. Simanek
https://www.nature.com/articles/nrg3763
Jul 15, 2014 · Synthetic delivery vectors have the potential to address many of the limitations of viral vectors, particularly with respect to safety. For systemic delivery of DNA, both lipid-based vectors and ...Author: Hao Yin, Rosemary L. Kanasty, Ahmed A. Eltoukhy, Arturo J. Vegas, Arturo J. Vegas, J. Robert Dorkin,...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2782077/
Oct 16, 2009 · Gene therapy is becoming a promising therapeutic modality for the treatment of genetic and acquired disorders. Nonviral approaches as alternative gene transfer vehicles to the popular viral vectors have received significant attention because of their favorable properties, including lack of immunogenicity, low toxicity, and potential for tissue specificity.Author: Mohammed S. Al-Dosari, Xiang Gao
https://www.researchgate.net/publication/280122514_Challenges_in_CRISPRCAS9_Delivery_Potential_Roles_of_Nonviral_Vectors
Challenges in CRISPR/CAS9 Delivery: Potential Roles of Nonviral Vectors Article (PDF Available) in Human gene therapy 26(7):452-62 · July 2015 with 4,717 Reads How we measure 'reads'
https://pubs.acs.org/doi/abs/10.1021/acs.chemrev.6b00799
Herein, we review the rapidly developing CRISPR/Cas9-based technologies for disease modeling and gene correction and recent progress toward Cas9/guide RNA …Author: Hong-Xia Wang, Mingqiang Li, Ciaran M. Lee, Syandan Chakraborty, Hae-Won Kim, Gang Bao, Kam W. Leong
https://www.scirp.org/reference/ReferencesPapers.aspx?ReferenceID=686046
M. A. Mintzer, E. E. Simanek. “Nonviral vectors for gene delivery,” Chem Rev., vol. 109, pp.259-302, April 2009.
https://www.ncbi.nlm.nih.gov/pubmed/28640612
Aug 09, 2017 · Chem Rev. 2017 Aug 9;117(15):9874-9906. doi: 10.1021/acs.chemrev.6b00799. ... (gRNA) delivery based on viral and nonviral vectors. We discuss the relative merits of delivering the genome editing elements in the form of DNA, mRNA, or protein, and the opportunities of combining viral delivery of a transgene encoding Cas9 with nonviral delivery of ...Author: Hong-Xia Wang, Mingqiang Li, Ciaran M. Lee, Syandan Chakraborty, Hae-Won Kim, Gang Bao, Kam W. Leong
https://link.springer.com/chapter/10.1007%2F978-3-319-78259-1_2
Jul 19, 2018 · Although viral vectors comprise the majority of gene delivery vectors, their various safety, production, and other practical concerns have left a research gap to be addressed. The non-viral vector space encompasses a growing variety of physical and chemical methods capable of gene delivery into the nuclei of target cells.Author: Chi Hong Sum, Samantha Marisha Shortall, Shirley Wong, Shawn David Wettig
https://www.nature.com/articles/3302534
Apr 28, 2005 · Nonviral gene delivery is limited to a large extent by multiple extracellular and intracellular barriers. One of the major barriers, especially in nondividing cells, is the nuclear envelope. Once ...Author: D A Dean, D D Strong, W E Zimmer
https://link.springer.com/chapter/10.1007%2F978-1-59259-705-5_6
Abstract. Gene therapy became a clinical reality when Rosenberg et al. (1) treated two young patients with adenine deaminase (ADA) deficiency with a retroviral vector that had been biotechnologic ally manipulated to encode for human ADA. Since 1990, approx 300 clinical trials, with a total of over 2000 volunteers or patients participating, have been conducted.Author: Frank L. Sorgi, Hans Schreier
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