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https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2692493/
Jun 01, 2009 · A number of nonviral siRNA delivery approaches have now been reported in vivo, including in nonhuman primates and humans 6 – 14. Non-viral vectors for siRNA delivery Of primary consideration in deciding on a drug delivery system for siRNA is whether the intended disease target lends itself to systemic or local administration.Author: Kun Gao, Leaf Huang
https://pubs.acs.org/doi/10.1021/mp800134q
Small interfering RNAs (siRNA) therapeutics has developed rapidly and already there are clinical trials ongoing or planned. Although other challenges remain, delivery strategies for siRNA become the main hurdle that must be resolved prior to the full-scale clinical development of siRNA therapeutics.Author: Kun Gao, Leaf Huang
https://www.researchgate.net/publication/23713164_Nonviral_Methods_for_siRNA_Delivery
Download Citation Nonviral Methods for siRNA Delivery RNA interference (RNAi) as a mechanism to selectively degrade mRNA (mRNA) expression has emerged as a potential novel approach for drug ...
https://www.europepmc.org/articles/PMC2692493/
May 01, 2009 · Local delivery of siRNA to the CNS is a feasible option for targeting CNS-based diseases, though systemic delivery strategies may be clinically more attractive. The delivery of siRNA targeting the NR2B subtype of the NMDA receptor using intrathecal injection led to a 83% decrease in the protein’s expression level in the rat brain 70 .Author: Kun Gao, Leaf Huang
https://www.altmetric.com/details/6106882
Nonviral Methods for siRNA Delivery. Overview of attention for article published in Molecular Pharmaceutics, December 2008. Altmetric Badge. About this Attention Score Above-average Attention Score compared to outputs of the same age (64th percentile)
https://www.sciencedirect.com/science/article/pii/S0301472X1100405X
Thus, transfection efficiencies in primary cells after Accell delivery was 85% (range, 71–97%) compared to 38% (23–65%) using Nucleofection for siRNA delivery. Preliminary studies of clonal growth of primary acute myeloid leukemia cells indicated growth inhibition after siRNA transfection.Author: Hanne Østergård Larsen, Anne Stidsholt Roug, Katrine Nielsen, Claus Svane Søndergaard, Peter Hokland
https://www.intechopen.com/books/gene-therapy-tools-and-potential-applications/non-viral-delivery-systems-in-gene-therapy
Non-Viral Delivery Systems in Gene Therapy. By Alicia Rodríguez Gascón, Ana del Pozo-Rodríguez and María Ángeles Solinís. ... Recent studies showed that the dendrimer-mediated siRNA delivery and gene silencing depends on the stoichiometry, ... also called hydrodynamic gene delivery method, is the most commonly method used for gene ...Author: Alicia Rodríguez Gascón, Ana del Pozo-Rodríguez, María Ángeles Solinís
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1559924/
Jun 25, 2006 · In this review we will focus on strategies for targeted siRNA delivery that are designed to improve accumulation of siRNA at three in vivo levels of delivery: at the target tissue, the target cell, and at the intracellular target site of action.Author: Sabrina Oliveira, Gert Storm, Raymond M. Schiffelers
https://www.nature.com/articles/nrg3763
Jul 15, 2014 · Gene-based therapy is the intentional modulation of gene expression in specific cells to treat pathological conditions. This modulation is accomplished by introducing exogenous nucleic acids such as DNA, mRNA, small interfering RNA (siRNA), microRNA (miRNA) or antisense oligonucleotides.Author: Hao Yin, Rosemary L. Kanasty, Ahmed A. Eltoukhy, Arturo J. Vegas, Arturo J. Vegas, J. Robert Dorkin,...
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