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https://www.liebertpub.com/doi/10.1089/hum.1997.8.10-1243
The aim of this study was to establish a nonviral method for gene delivery to the rat kidney. To this purpose, a panel of reagents was tested, including a monocationic lipid, DOTAP, a polycationic lipid, DOGS (or Transfectam), and three different forms of the cationic polymer polyethylenimine (PEI).Author: Alessandra Boletta, Ariela Benigni, Jens Lutz, Giuseppe Remuzzi, Marco R. Soria, Lucia Monaco
https://moh-it.pure.elsevier.com/en/publications/nonviral-gene-delivery-to-the-rat-kidney-with-polyethylenimine
title = "Nonviral gene delivery to the rat kidney with polyethylenimine", abstract = "The aim of this study was to establish a nonviral method for gene delivery to the rat kidney.Author: Alessandra Boletta, Ariela Benigni, Jens Lutz, Giuseppe Remuzzi, Marco R. Soria, Lucia Monaco
https://europepmc.org/abstract/MED/9215741
Aug 01, 1997 · The aim of this study was to establish a nonviral method for gene delivery to the rat kidney. To this purpose, a panel of reagents was tested, including a monocationic lipid, DOTAP, a polycationic lipid, DOGS (or Transfectam), and three different forms of the cationic polymer polyethylenimine (PEI).Author: Alessandra Boletta, Ariela Benigni, Jens Lutz, Giuseppe Remuzzi, Marco R. Soria, Lucia Monaco
http://www.nature.com/articles/3301407
Apr 18, 2001 · In the present studies, we have used a cationic polymer, polyethylenimine (PEI) coupled to an anti-CD3 antibody for achieving receptor-mediated gene delivery to human peripheral blood mononuclear ...Author: MM O'Neill, CA Kennedy, RW Barton, RJ Tatake
https://www.sciencedirect.com/science/article/pii/S0168365903000762
Gene delivery to rat kidneys following injection into the renal artery was higher for branched HMW-PEI than for linear PEI 22 kDa . On the other hand, Wightman and colleagues [9] found that linear PEI 22 kDa was more effective than branched HMW-PEI both under in vitro and in vivo conditions.Author: Klaus Kunath, Anke von Harpe, Dagmar Fischer, Holger Petersen, Ulrich Bickel, Karlheinz Voigt, Thoma...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6171788/
Jul 03, 2018 · 1.1. Recent advances in non-viral gene therapy and in vitro/vivo delivery systems. The theory of gene therapy is that treating or preventing genetic disorders by repairing abnormal or replacing the lost genes that have been accelerated over the past few decades as a powerful tool for the treatment of genetic disorders and cancer.Author: Abbas Zakeri, Mohammad Amin Jadidi Kouhbanani, Nasrin Beheshtkhoo, Vahid Beigi, Seyyed Mojtaba Mousa...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2935311/
The route of delivery into the kidney will prove to be an important factor regardless of the vector being considered for use as a gene therapy vehicle. In this review, we will discuss the pros and cons of the well-known viral vector systems in the context of the kidney, and discuss other gene therapy applications that may provide therapeutic potential in the future.Author: Talha Akbulut, Frank Park
https://www.telethon.it/cosa-facciamo/ricerca/progetti-finanziati/gene-transfer-to-the-art-kidney-using-the-in-vitro-amplification-expression-system-to-elucidate-the-role-of-endothelin-1-in-glomerulosclerosis
1997 HUMAN GENE THERAPY Nonviral gene delivery to the rat kidney with polyethylenimine; 1997 NUCLEIC ACIDS RESEARCH Nanoscopic structure of DNA condensed for gene delivery; 2000 NEPHRON Nonviral and viral gene transfer to the kidney in the context of transplantation
https://link.springer.com/content/pdf/10.1023%2FA%3A1014861900478.pdf
LMW-PEI (Mw 11′900 D) with a low degree of branching was synthesized as a DNA carrier for gene delivery. In contrast to high molecular weight polyethylenimines (HMW-PEI; Mw l′616′OOO D ), the polymer described here showed a different degree of branching and was less cytotoxic in a broad range of concentrations.Author: Dagmar Fischer, Thorsten Bieber, Youxin Li, Hans-Peter Elsässer, Thomas Kissel
https://www.nature.com/articles/3301092
Feb 17, 2000 · Gene transfer to the kidney can be achieved with various DNA vectors, resulting in transgene expression in glomerular or tubular districts. Controlling transgene destination is desirable for ...Author: C Foglieni, A Bragonzi, M Cortese, L Cantù, A Boletta, I Chiossone, M R Soria, L Monaco
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