Nonviral Gene Delivery Vectors

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Viral and nonviral delivery systems for gene delivery

    https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3507026/
    Jul 06, 2012 · There are different viral and nonviral vectors for gene delivery, but all gene therapy applications depend on the fact that the genetic material needs to be delivered across the cell membrane and ultimately to the cell nucleus.

Nonviral Gene Delivery: Principle, Limitations, and Recent ...

    https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2782077/
    Oct 16, 2009 · Gene therapy is becoming a promising therapeutic modality for the treatment of genetic and acquired disorders. Nonviral approaches as alternative gene transfer vehicles to the popular viral vectors have received significant attention because of their favorable properties, including lack of immunogenicity, low toxicity, and potential for tissue specificity.Author: Mohammed S. Al-Dosari, Xiang Gao

Gene Therapy Non-Viral Vectors Explained

    http://www.genetherapynet.com/non-viral-vectors.html
    Non-Viral Vectors Previously, low levels of transfection and expression of the gene held non-viral methods at a disadvantage; however, recent advances in vector technology have yielded molecules and techniques with transfection efficiencies similar to those of viruses .

Nonviral cancer gene therapy: Delivery cascade and vector ...

    https://www.ncbi.nlm.nih.gov/pubmed/28778715
    Jun 01, 2017 · Gene therapy represents a promising cancer treatment featuring high efficacy and limited side effects, but it is stymied by a lack of safe and efficient gene-delivery vectors. Cationic polymers and lipid-based nonviral gene vectors have many advantages and have been extensively explored for cancer gene delivery, but their low gene-expression ...

Nonviral Vectors for Gene Delivery Chemical Reviews

    https://pubs.acs.org/doi/10.1021/cr800409e
    Dec 03, 2008 · Cationic Amino Acid Based Lipids as Effective Nonviral Gene Delivery Vectors for Primary Cultured Neurons. ACS Chemical Neuroscience 2013, 4 (12) , 1514-1519. DOI: 10.1021/cn400036j. Yang Yang, Ying-Ming Zhang, Yong Chen, Jia-Tong Chen, and Yu Liu .Author: Meredith A. Mintzer, Eric E. Simanek

(PDF) Nanoparticles as Nonviral Gene Delivery Vectors

    https://www.researchgate.net/publication/5633360_Nanoparticles_as_Nonviral_Gene_Delivery_Vectors
    Nanoparticles as Nonviral Gene Delivery Vectors. ... nonviral vectors have recently received an ever increasing attention in order to overcome the safety problems of their viral counterpart. This ...

Non-Viral Vector Gene Delivery - Polyplus-transfection

    https://www.polyplus-transfection.com/blog/non-viral-vector-mediated-gene-delivery/
    Although non-viral vectors represent a small percentage of ongoing Human gene therapy clinical trials, PEI-based non-viral delivery is increasingly used in treatments of pathologies such as cancer (eg. bladder, ovarian, pancreatic, small-cell lung cancer), and in immunotherapy (eg.

Viral vs. Nonviral in Gene Therapy: Which Vector Will Prevail?

    https://www.the-scientist.com/news/viral-vs-nonviral-in-gene-therapy-which-vector-will-prevail-56938
    Jun 22, 1998 · Viral vs. Nonviral in Gene Therapy: Which Vector Will Prevail? Pointing to a few empty chairs in a conference room, moderator David T. Curiel joked that a symposium on emerging nonviral vectors was a "failure" compared to other packed talks at the American Society of Gene Therapy's inaugural meeting last month.

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