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https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2896879/
Mesenchymal stem cells (MSCs) hold a great promise for application in several therapies due to their unique biological characteristics. In order to harness their full potential in cell-or gene-based therapies it might be advantageous to enhance some of their features through gene delivery strategies.Author: C. Madeira, R. D. Mendes, S. C. Ribeiro, J. S. Boura, M. R. Aires-Barros, C. L. da Silva, J. M. S. C...
https://onlinelibrary.wiley.com/doi/full/10.1002/bit.26870
Therefore, more efficient and less toxic nonviral gene delivery methods to hMSCs are needed to advance their potential clinical applications. To improve nonviral gene delivery, our group has focused on elucidating the biology of transfection to develop new strategies for improved efficiency.Author: Andrew Hamann, Kelly Broad, Albert Nguyen, Angela K. Pannier
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3668965/
Genetically modified mesenchymal stem cells (MSCs) have great potential in the application of regenerative medicine and molecular therapy. In the present manuscript, we introduce a nanopolymer, polyethylenimine 600-β-cyclodextrin (PEI 600-β-CyD), as an efficient polyplex-forming plasmid delivery agent with low toxicity and ideal transfection efficiency on primary MSCs.Author: Haijun Tong, Chuandong Wang, Yan Huang, Qin Shi, Julio C Fernandes, Kerong Dai, Guping Tang, Xiaolin...
http://www.eurekaselect.com/73252/article
Suicide Gene Therapy Against Malignant Gliomas by the Local Delivery of Genetically Engineered Umbilical Cord Mesenchymal Stem Cells as Cellular Vehicles Current Gene Therapy; Nano-enhanced Optical Gene Delivery to Retinal Degenerated Mice Current Gene Therapy; The Therapeutic Potential and Role of miRNA, lncRNA, and circRNA in Osteoarthritis ...Author: Jose L. Santos, Deepti Pandita, Joao Rodrigues, Ana P. Pego, Pedro L. Granja, Helena Tomas
https://www.researchgate.net/publication/265734034_Genetic_engineering_of_mesenchymal_stem_cells_by_non-viral_gene_delivery
Genetic engineering of mesenchymal stem cells by non-viral gene delivery. Article · Literature Review ... If nonviral gene delivery to MSCs can be sufficiently improved, MSC therapies could be ...
https://www.hindawi.com/journals/sci/2013/326828/
Intervertebral disc (IVD) cell therapy with unconditioned 2D expanded mesenchymal stem cells (MSC) is a promising concept yet challenging to realize. Differentiation of MSCs by nonviral gene delivery of growth and differentiation factor 5 (GDF5) by electroporation mediated gene transfer could be an excellent source for cell transplantation.Author: Christian H. Bucher, Amiq Ur Rahman Gazdhar, Lorin M. Benneker, Thomas Geiser, Benjamin Gantenbein-R...
https://www.nature.com/articles/gt2011139
Sep 29, 2011 · Nonviral gene delivery of erythropoietin by mesenchymal stromal cells. ... Gene transfer into rat mesenchymal stem cells: a comparative study of viral and nonviral vectors.Author: F Scheibe, N Gladow, P Mergenthaler, A H Tucker, A Meisel, D J Prockop, J Priller
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