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https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2782077/
Oct 16, 2009 · Nonviral methods are generally viewed as less efficacious than the viral methods, and in many cases, the gene expression is short-lived. However, recent developments suggest that gene delivery by some physical methods has reached the efficiency …Author: Mohammed S. Al-Dosari, Xiang Gao
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3507026/
Jul 06, 2012 · Physical methods of nonviral gene delivery. Physical methods applied for in vitro and in vivo gene delivery are based on making transient penetration in cell membrane by mechanical, electrical, ultrasonic, hydrodynamic, or laser-based energy so that DNA entrance into the targeted cells is facilitated.
https://www.sciencedirect.com/science/article/pii/S0168365915302649
During the earlier stages of gene therapy development, non-viral gene therapies were considered clinically unfeasible due to their poor gene delivery efficiency compared to viral delivery systems. Nonetheless, tremendous research efforts and advancements have brought nanoparticle-based non-viral gene delivery vectors one step closer to the clinic.Author: Marianna Foldvari, Ding Wen Chen, Nafiseh Nafissi, Daniella Calderon, Lokesh Narsineni, Amirreza Raf...
https://www.researchgate.net/publication/235727655_Non-Viral_Gene_Delivery_Methods
As an alternative to viral gene delivery, nonviral gene delivery has emerged as a more cost-effective option with the ability to deliver larger genetic cargoes, improved scalability, and lower ...
https://www.intechopen.com/books/gene-therapy-tools-and-potential-applications/non-viral-delivery-systems-in-gene-therapy
The simplicity is one of the characteristics of these methods. The genetic material is introduced into cells without formulating in any particulate or viral system. In a recent publication, Kamimura et al. revised the different physical methods for gene delivery. These methods include the following:Author: Alicia Rodríguez Gascón, Ana del Pozo-Rodríguez, María Ángeles Solinís
https://www.researchgate.net/publication/233841223_Viral_and_nonviral_delivery_systems_for_gene_delivery
Although numerous viral and nonviral gene delivery systems have been developed in the last 3 decades, no delivery system has been designed that can be applied in gene therapy of all kinds of cell ...
http://www.eurekaselect.com/106191/article
In order to improve gene transfer efficacy, a lot of efforts have been made in the past years, and numerous gene carriers and techniques have been developed. In this review, we summarized the features, drawbacks and prospects of existing and emerging non-viral gene delivery methods.
https://www.sciencedirect.com/topics/neuroscience/nonviral-gene-delivery-system
Of the physical methods of nonviral gene delivery, electroporation is the most developed and has had the greatest impact to date. The benefits of electroporation in gene delivery are evident: reduced inflammation and immune response, ease and relatively low cost of instrumentation, and increasing levels of gene transfer and expression, nearing ...
http://www.genetherapynet.com/non-viral-vectors.html
This success, however, does not compare to that of the other methods, leading to research into more efficient methods for delivery of the naked DNA such as electroporation and the use of a "gene gun", which shoots DNA coated gold particles into the cell using high pressure gas.
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