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https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2527668/
Although the definition identifies nanoparticles as having dimensions below 0.1 μm or 100 nm, especially in the area of drug delivery relatively large (size >100 nm) nanoparticles may be needed for loading a sufficient amount of drug onto the particles.Author: Wim H De Jong, Paul Ja Borm
https://www.nature.com/articles/natrevmats201614
Apr 26, 2016 · Targeting nanoparticles to malignant tissues for improved diagnosis and therapy is a popular concept. However, after surveying the literature from the past 10 years, only 0.7% (median) of …Author: Stefan Wilhelm, Anthony J. Tavares, Qin Dai, Seiichi Ohta, Seiichi Ohta, Julie Audet, Harold F. Dvor...
https://www.nature.com/articles/s41551-017-0137-2
Lee, K., Conboy, M., Park, H.M. et al. Nanoparticle delivery of Cas9 ribonucleoprotein and donor DNA in vivo induces homology-directed DNA repair. Nat Biomed Eng 1, 889–901 (2017 ...Author: Kunwoo Lee, Michael Conboy, Hyo Min Park, Fuguo Jiang, Hyun Jin Kim, Hyun Jin Kim, Mark A. Dewitt, V...
https://www.understandingnano.com/nanotechnology-drug-delivery.html
Perhaps the most publicized use of nanotechnology in drug delivery under development is the use of nanoparticles to deliver drugs to cancer cells. Particles are engineered so that they are attracted to diseased cells, which allows direct treatment of those cells.
https://www.pnas.org/content/108/6/2426
Feb 08, 2011 · Multistage nanoparticle systems provide additional tunability in the spatial control of delivery to solid tumors. Because of the multiple physiological barriers that a therapeutic agent must encounter, a multistage nanoparticle system can enhance penetration by changing its size, charge, shape, flexibility, and/or surface coating to suit the transport across each barrier.Author: Cliff Wong, Triantafyllos Stylianopoulos, Jian Cui, John Daniel Martin, Vikash P. Chauhan, Wen Jiang...
https://www.sciencedirect.com/science/article/pii/S0169409X08000999
Gold nanoparticles (AuNPs) provide non-toxic carriers for drug and gene delivery applications. With these systems, the gold core imparts stability to the assembly, while the monolayer allows tuning of surface properties such as charge and hydrophobicity.Author: Partha Ghosh, Gang Han, Mrinmoy De, Chae Kyu Kim, Vincent M. Rotello
https://www.sciencedirect.com/topics/chemistry/gold-nanoparticle
Gold nanoparticles are considered to be an efficient system for delivery of either DNA or RNA for gene silencing and consequently for therapeutic purposes. Mirkin et al. demonstrated that a dense layer of ssDNA molecules can coat the surface of citrate stabilized spherical nanoparticles via thiol linkers and hence can be exploited for gene silencing.
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