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https://www.sciencedirect.com/science/article/abs/pii/S0010854518301127
To address these issues, several non-viral gene delivery vectors are being explored. Among these non-viral vectors, multifunctional nanoparticles have shown superior performance in terms of enhanced gene stability, shielding of cargo from nuclease degradation, and improved passive/active targeting.Author: Guimiao Lin, Li Li, Nishtha Panwar, Jie Wang, Swee Chuan Tjin, Xiaomei Wang, Ken-Tye Yong
https://www.sciencedirect.com/science/article/pii/S0010854518301127
4. Multifunctional nanoparticles for gene delivery. Despite the potentially higher biosafety of non-viral vectors in gene delivery, the therapeutic effect of single-functional non-viral vectors is far from satisfactory. In order to manage the challenges associated with non-viral vectors, multifunctional nanoparticles have been introduced.Author: Guimiao Lin, Li Li, Nishtha Panwar, Jie Wang, Swee Chuan Tjin, Xiaomei Wang, Ken-Tye Yong
https://www.researchgate.net/publication/26837587_Non-viral_gene_delivery_using_nanoparticles
Non-viral gene delivery using nanoparticles. ... In this article, current non-viral gene delivery devices are reviewed with a special emphasis on nanoparticle gene delivery systems. Also, the ...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4347098/
Jan 01, 2015 · The major advantage of using non-viral vectors is its bio-safety. However the application of non-viral gene transfer have been ignored for a long time in past because of their poor efficiency of delivery thereby low transient expression of their transgenes . Non-viral vectors have drawn significant attention due to its less immunotoxicity.Author: Murali Ramamoorth, Aparna Narvekar
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4046008/
May 21, 2014 · Polymer-based nanoparticles. Cationic polymers are one of the most significant non-viral gene delivery systems. These polymers have positively charged groups in their backbone and can interact with the negative charge of anionic genetic materials [].Cationic polymers can bind to DNA molecules to form neutralized, nanometer-sized complexes known as polyplexes.Author: Solmaz Maleki Dizaj, Samira Jafari, Ahmad Yari Khosroushahi
https://www.intechopen.com/books/gene-therapy-tools-and-potential-applications/non-viral-delivery-systems-in-gene-therapy
Gene delivery systems include viral vectors and non-viral vectors. Viral vectors are the most effective, but their application is limited by their immunogenicity, oncogenicity and the small size of the DNA they can transport. Non-viral vectors are safer, of low cost, more reproducible and do not present DNA size limit.Author: Alicia Rodríguez Gascón, Ana del Pozo-Rodríguez, María Ángeles Solinís
https://www.researchgate.net/publication/305655393_Nanoparticles_in_Gene_Therapy
A major approach discussed is the use of Nanoparticles as non-viral carriers for gene delivery purposes regarding their favorable characteristics such as their nano-metric size, high surface to ...
https://link.springer.com/chapter/10.1007%2F978-3-319-78259-1_2
Jul 19, 2018 · Although viral vectors comprise the majority of gene delivery vectors, their various safety, production, and other practical concerns have left a research gap to be addressed. The non-viral vector space encompasses a growing variety of physical and chemical methods capable of gene delivery into the nuclei of target cells.Author: Chi Hong Sum, Samantha Marisha Shortall, Shirley Wong, Shawn David Wettig
https://www.nature.com/articles/s41598-020-61465-6
Mar 12, 2020 · Several non-viral delivery vehicles have been developed for delivery of CRISPR/Cas9 such as human serum albumin nanoparticles (NPs), lipid NPs and gold NPs 10,11,12.Author: S. S. Rohiwal, N. Dvorakova, J. Klima, M. Vaskovicova, F. Senigl, M. Slouf, E. Pavlova, P. Stepanek,...
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