Nonviral Gene Delivery And Therapeutics Targeting To Brain

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Non-viral Gene Delivery and Therapeutics Targeting to Brain

    http://www.eurekaselect.com/73191/article
    The nonviral nano-scaled gene delivery systems hold great promise for treating brain diseases due to their safety and convenience. Several brain targeting strategies, such as adsorptive- and receptor-mediated pathways have been developed to improve the brain targeting efficiency of non-viral gene delivery systems.Author: Yang Liu, Rongqin Huang, Chen Jiang

Development of Nonviral Vectors Targeting the Brain as a ...

    https://www.sciencedirect.com/science/article/pii/S1525001616309984
    Nonviral vectors mediate transvascular delivery of siRNA and gene knockdown in vivo. ( a ) Naive mice ( n = 5) were injected intravenously with PBS (control) or biotinylated-C2-9r in PBS. The animals were sacrificed at indicated time points postinjection after which the brains were collected and postfixed.Author: Hayate Javed, Sindhu A Menon, Karima M Al-Mansoori, Abdelmojib Al-Wandi, Nour K Majbour, Mustafa T A...

Non-viral Gene Delivery and Therapeutics Targeting to Brain

    http://adsabs.harvard.edu/abs/2011CNan....7...55L
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Gene therapy of the brain Neurology

    https://n.neurology.org/content/62/8/1275
    Apr 27, 2004 · Nonviral, noninvasive gene therapy of the brain is now possible with the development of a new approach to targeting therapeutic genes to the brain following an IV administration. This approach utilizes genetically engineered molecular Trojan horses, which ferry the gene across the BBB and into neurons.Author: Felix Schlachetzki, Yun Zhang, Ruben J. Boado, William M. Pardridge

Development of Nonviral Vectors Targeting the Brain as a ...

    https://www.cell.com/molecular-therapy-family/molecular-therapy/pdf/S1525-0016(16)30998-4.pdf
    Development of Nonviral Vectors Targeting the Brain as a Therapeutic Approach For Parkinson’s Disease and Other Brain Disorders original article © The American Society of Gene & Cell Therapy Parkinson’s disease (PD) is a debilitating neurodegenera- …

Development of Nonviral Vectors Targeting the Brain as a ...

    https://www.cell.com/molecular-therapy-family/molecular-therapy/fulltext/S1525-0016(16)30998-4
    Apr 01, 2016 · Development of Nonviral Vectors Targeting the Brain as a Therapeutic Approach For Parkinson's Disease and Other Brain Disorders Parkinson's disease (PD) is a debilitating neurodegenerative disease characterized by tremor, rigidity, bradykinesia, and postural instability, for which there is no effective treatment available till date.Author: Hayate Javed, Sindhu A Menon, Karima M Al-Mansoori, Abdelmojib Al-Wandi, Nour K Majbour, Mustafa T A...

Blood-brain barrier delivery of protein and non-viral gene ...

    https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2701689/
    Oct 08, 2007 · 3. Delivery of protein therapeutics across the human blood-brain barrier with genetically engineered fusion proteins. The HIRMAb has been developed for brain drug targeting in humans, because the BBB transport activity of this MTH is nearly 10-fold greater than that of the TfRMAb . The murine HIRMAb cannot be used in humans.Author: William M. Pardridge

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