We have collected information about Nonviral Gene Delivery for you. Follow the links to find out details on Nonviral Gene Delivery.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2782077/
Oct 16, 2009 · The nonviral gene delivery methods, on the other hand, use synthetic or natural compounds or physical forces to deliver a piece of DNA into a cell. The materials used are generally less toxic and immunogenic than the viral counterparts.Author: Mohammed S. Al-Dosari, Xiang Gao
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3507026/
Jul 06, 2012 · Physical methods of nonviral gene delivery. Physical methods applied for in vitro and in vivo gene delivery are based on making transient penetration in cell membrane by mechanical, electrical, ultrasonic, hydrodynamic, or laser-based energy so that DNA entrance into the targeted cells is facilitated.
https://ir.uiowa.edu/etd/1577/
Gene therapy is being intensively studied as a potential method to treat many disorders, including disorders of the liver. While viral gene therapy has seen some success, possible side effects make it risky, so nonviral gene delivery vectors are being developed.Author: Samuel Thomas Crowley
https://pubs.acs.org/doi/10.1021/mp400467x
Oct 04, 2013 · A key end goal of gene delivery research is to develop clinically relevant vectors that can be used to combat elusive diseases such as AIDS. Despite promising engineering strategies, efficiency and ultimately gene modulation efficacy of nonviral vectors have been hindered by numerous in vitro and in vivo barriers that have resulted in subviral performance. In this perspective, we concentrate ...Author: Charles H. Jones, Chih-Kuang Chen, Anitha Ravikrishnan, Snehal Rane, Blaine A. Pfeifer
https://pubs.acs.org/doi/10.1021/acs.accounts.8b00665
Nonviral gene delivery to the liver has been under evolution for nearly 30 years. Early demonstrations established relatively simple nonviral vectors could mediate gene expression in HepG2 cells which understandably led to speculation that these same vectors would be immediately successful at transfecting primary hepatocytes in vivo.Author: Craig Van Bruggen, Joseph K. Hexum, Zhe Tan, Rishad J. Dalal, Theresa M. Reineke
https://www.pnas.org/content/115/19/4903
May 08, 2018 · P-HNPs could also mediate gene knock-in and gene activation. In vivo studies further indicated the efficiency of this nonviral gene-editing system for topical anticancer therapy. Given the potency of PPABLG for systemic siRNA delivery in vivo, this work suggests the broad potential of P-HNPs for nonviral gene editing.Author: Hong Xia Wang, Ziyuan Song, Yeh Hsing Lao, Xin Xu, Jing Gong, Du Cheng, Syandan Chakraborty, Ji Sun ...
https://www.sciencedirect.com/science/article/pii/B9780128144701000101
It is usually obtained by deacetylation of chitin, the main component of the exoskeleton of crustaceans. 206 Because of its biocompatibility, biodegradability, low cytotoxicity, and multiple functionalities, CS has been investigated intensively as a nonviral gene delivery vector. Every deacetylated subunit in CS contains a primary amine group ...Author: Dezhong Zhou, Ming Zeng, Yongsheng Gao, A. Sigen, Jing Lyu, Wenxin Wang
https://www.intechopen.com/books/gene-therapy-tools-and-potential-applications/non-viral-delivery-systems-in-gene-therapy
Alicia Rodríguez Gascón, Ana del Pozo-Rodríguez and María Ángeles Solinís (February 27th 2013). Non-Viral Delivery Systems in Gene Therapy, Gene Therapy - Tools and Potential Applications, Francisco Martin Molina, IntechOpen, DOI: 10.5772/52704. Available from:Author: Alicia Rodríguez Gascón, Ana del Pozo-Rodríguez, María Ángeles Solinís
https://www.pnas.org/content/102/32/11539
Aug 09, 2005 · Abstract. This article reports on the application of organically modified silica (ORMOSIL) nanoparticles as a nonviral vector for efficient in vivo gene delivery. Highly monodispersed, stable aqueous suspension of nanoparticles, surface-functionalized with amino groups for binding of DNA, were prepared and characterized.Author: Dhruba J. Bharali, Ilona Klejbor, Ewa K. Stachowiak, Purnendu Dutta, Indrajit Roy, Navjot Kaur, Earl...
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