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https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3507026/
Jul 06, 2012 · Although numerous viral and nonviral gene delivery systems have been developed in the last 3 decades, no delivery system has been designed that can be applied in gene therapy of all kinds of cell types in vitro and in vivo with no limitation and side effects.
https://www.intechopen.com/books/gene-therapy-tools-and-potential-applications/non-viral-delivery-systems-in-gene-therapy
Since the initial studies, hundreds of cationic lipids have been synthesized as candidates for non-viral gene delivery and a few made it to clinical trials [85,86]. Cationic lipids can be used to form lipoplexes by directly mixing the positively charged lipids at the physiological pH with the negatively charged DNA.Author: Alicia Rodríguez Gascón, Ana del Pozo-Rodríguez, María Ángeles Solinís
http://www.eurekaselect.com/106191/article
In order to improve gene transfer efficacy, a lot of efforts have been made in the past years, and numerous gene carriers and techniques have been developed. In this review, we summarized the features, drawbacks and prospects of existing and emerging non-viral gene delivery methods.
https://onlinelibrary.wiley.com/doi/full/10.1002/jgm.3092
Apr 16, 2019 · Non‐viral gene delivery systems show a lower transfection efficacy and transient gene expression compared to viral vectors; however, non‐viral vectors are of much lower immunogenicity than the viral vectors.Author: Weiqi Wang, Weiqi Wang, Madiha Saeed, Yao Zhou, Lili Yang, Dangge Wang, Haijun Yu
http://juventasinc.com/non-viral-gene-therapy.html
A non-viral DNA plasmid is delivered directly to the site of injured tissue creating a localized homing signal at the site of delivery, with no significant expression of the …
Learn how BMoGen is utilizing their unique expertise to provide gene editing services including fee-for-service and non-viral transposon based gene delivery platforms that address complex gene delivery and gene editing enabling scientists and bio-therapeutics companies to create life …
https://www.sciencedirect.com/science/article/pii/S0168365918301202
Non-viral gene delivery methods like electroporation and chemical transfection reagents are an attractive alternative due to their reduced cost, their easy adaptation to various cargo, and their improved safety profile compared to viral vectors but historically have low gene transfer …Author: Brynn R. Olden, Yilong Cheng, Jonathan L. Yu, Suzie H. Pun
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4347098/
Jan 01, 2015 · The non-viral vectors are Naked DNA, particle based and chemical based. They are administered by direct administration (plasmid DNA/Naked DNA)/ chemical /physical. Most of cardiovascular clinical trials use non-viral vectors as a mode of gene transfer.Author: Murali Ramamoorth, Aparna Narvekar
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