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https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2844929/
Introduction: red blood cells as carriers for drug delivery The optimization of vascular delivery of drugs is an important biomedical problem. This problem is especially acute in case of delivery of potent and specific, yet labile and complex biotherapeutic agents including enzymes, which in most cases require precise localization in the target site.
https://www.nature.com/articles/s41467-018-04791-8
Jun 15, 2018 · Here the authors produce extracellular vesicles from red blood cells for in vivo cargo delivery. RNA delivery for disease treatment often has low uptake efficiencies and cytotoxicity.Author: Waqas Muhammad Usman, Tin Chanh Pham, Yuk Yan Kwok, Luyen Tien Vu, Victor Ma, Boya Peng, Yuen San Ch...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5424548/
Nov 15, 2016 · Red blood cells (RBCs) constitute a unique drug delivery system as a biologic or hybrid carrier capable of greatly enhancing pharmacokinetics, altering pharmacodynamics (for example, by changing margination within the intravascular space), and modulating immune responses to …Author: Carlos H. Villa, Aaron C. Anselmo, Samir Mitragotri, Vladimir Muzykantov
https://www.medicalautomation.org/2020/04/drug-delivery-via-red-blood-cells/
Functionalized red blood cells for drug delivery “[R]esearchers at McMaster University in Canada have developed a way of emptying red blood cells, filling them with drugs, attaching a homing mechanism, and sending them out to find specific targets. “We call these super-human red blood cells,...
https://upenn.technologypublisher.com/technology/38534
The drug delivery system, “Red Blood Cell (RBC)-Hitchhiking Nanoparticles” (RHNs), utilizes soft nanoparticles, such as liposomes and nanogels, loaded with drugs and the natural properties of RBCs to target the lung endothelium. The nanoparticles are adsorbed …
https://www.onlinelibrary.wiley.com/doi/abs/10.1002/smtd.201700270
Nov 14, 2017 · Red blood cells (RBCs), or erythrocytes, have been promising endogenous candidates for drug delivery for more than four decades. Armed with a better understanding of the diverse mechanisms and paths for drug delivery, researchers have achieved great progress in manufacturing RBC‐based carriers, from both the scientific and clinical viewpoints.Author: Junjie Yan, Jicheng Yu, Chao Wang, Zhen Gu
https://advances.sciencemag.org/content/5/10/eaaw6870.full
Oct 01, 2019 · Erythrocytes or red blood cells (RBCs) represent a promising cell-mediated drug delivery platform due to their inherent biocompatibility. Here, we developed an antigen delivery system based on the nanoerythrosomes derived from RBCs, inspired by the splenic antigen-presenting cell targeting capacity of senescent RBCs.Author: Xiao Han, Shufang Shen, Qin Fan, Guojun Chen, Edikan Archibong, Gianpietro Dotti, Zhuang Liu, Zhen G...
https://www.nature.com/articles/s41467-018-05079-7
Jul 11, 2018 · To achieve this goal, we and others have explored the idea of combining nanomedicine with cell therapy, in particular, red blood cell (RBC) delivery. RBCs are a …Author: Jacob S. Brenner, Daniel C. Pan, Jacob W. Myerson, Oscar A. Marcos-Contreras, Carlos H. Villa, Priya...
https://www.technologyreview.com/s/544281/turning-red-blood-cells-into-versatile-drug-carriers/
Dec 09, 2015 · Genetically engineering red blood cells to turn them into drug-delivery vehicles could open the door to a vast number of new therapies. And since mature red cells don’t carry any genetic material, they would also carry fewer safety risks than other gene and cell therapies.Author: Mike Orcutt
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