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https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3507026/
Jul 06, 2012 · INTRODUCTION. Basically gene therapy is an intracellular delivery of genomic materials (transgene) into specific cells to generate a therapeutic effect by correcting an existing abnormality or providing the cells with a new function.[] Different types of gene delivery systems may be applied in gene therapy to restore a specific gene function or turning off a special gene(s).
https://www.intechopen.com/books/gene-therapy-tools-and-potential-applications/non-viral-delivery-systems-in-gene-therapy
Gene delivery systems include viral vectors and non-viral vectors. Viral vectors are the most effective, but their application is limited by their immunogenicity, oncogenicity and the small size of the DNA they can transport. Non-viral vectors are safer, of low cost, more reproducible and do not present DNA size limit.Author: Alicia Rodríguez Gascón, Ana del Pozo-Rodríguez, María Ángeles Solinís
https://www.intechopen.com/books/recent-advances-in-novel-drug-carrier-systems/gene-delivery-systems-recent-progress-in-viral-and-non-viral-therapy
Current gene delivery systems are divided into three categories: viral-based, non-viral based, and combined hybrid systems. Viral gene delivery systems consist of viruses that are modified to be replication-deficient which can deliver genes to the target cells to provide expression.Author: Erdal Cevher, Ali Demir Sezer, Emre Şefik Çağlar
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4347098/
Jan 01, 2015 · The major advantage of using non-viral vectors is its bio-safety. However the application of non-viral gene transfer have been ignored for a long time in past because of their poor efficiency of delivery thereby low transient expression of their transgenes . Non-viral vectors have drawn significant attention due to its less immunotoxicity.Author: Murali Ramamoorth, Aparna Narvekar
https://www.sciencedirect.com/science/article/pii/S0142961218302862
Nevertheless, with the rapid development of various synthetic vectors, non-viral vectors are very likely to provide unique advantages over viral vectors in these fields. Here, we review recent advances of non-viral vectors for CRISPR/Cas9 delivery in vivo and focus on those non-viral delivery systems applied for CRISPR/Cas9-based gene therapy.Author: Ling Li, Ling Li, Shuo Hu, Xiaoyuan Chen
https://translational-medicine.biomedcentral.com/articles/10.1186/s12967-018-1402-1
Feb 15, 2018 · Critical tissue defects frequently result from trauma, burns, chronic wounds and/or surgery. The ideal treatment for such tissue loss is autografting, but donor sites are often limited. Tissue engineering (TE) is an inspiring alternative for tissue repair and regeneration (TRR). One of the current state-of-the-art methods for TRR is gene therapy. Non-viral gene delivery systems (nVGDS) have ...Author: Pan Wu, Haojiao Chen, Ronghua Jin, Tingting Weng, Jon Kee Ho, Chuangang You, Liping Zhang, Xingang W...
https://www.slideshare.net/Aparajitha_Anne/gene-delivery-system
May 19, 2012 · Non-Viral delivery Systems:Non-viral delivery system has some advantages over viral system. Non-viralare simple and safer alternative for the viral systems and low hostimmunogenicity will be two. 18. Naturally Occurring compounds:It is simplest method of injecting naked DNA into the human body i.e. it alsocalled Naked DNA.
https://www.mdpi.com/journal/pharmaceutics/special_issues/nonviral_gene_delivery
Non-viral gene delivery systems have the potential to overcome these limitations, allowing not only a safe but also an efficient gene delivery process into target cells. This Special Issue has the aim of highlighting the current progress in non-viral gene delivery systems.
https://www.sciencedirect.com/science/article/pii/S095816690200294X
Apr 01, 2002 · Non-viral gene delivery systems have the potential to create viable pharmaceuticals from nucleic acids. These DNA delivery systems contain lipids and/or cationic polymers. In order for these systems to be developed into commercial products, several barriers must be overcome. These include obstacles in manufacturing, formulation and stability.Author: Mark E Davis
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