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https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3507026/
Jul 06, 2012 · Keywords: Chemical delivery, gene therapy, non viral delivery systems, physical delivery, viral delivery systems INTRODUCTION Basically gene therapy is an intracellular delivery of genomic materials (transgene) into specific cells to generate a therapeutic effect by correcting an existing abnormality or providing the cells with a new function.[ 1 ]
https://www.intechopen.com/books/gene-therapy-tools-and-potential-applications/non-viral-delivery-systems-in-gene-therapy
Non-Viral Delivery Systems in Gene Therapy 1. Introduction. Recent advances in molecular biology combined with the culmination... 2. Aim and concept of gene therapy with non-viral vectors. 3. Non-viral methods for transfection. Table 1 summarizes the most utilized non-viral …Author: Alicia Rodríguez Gascón, Ana del Pozo-Rodríguez, María Ángeles Solinís
https://www.ncbi.nlm.nih.gov/pubmed/28527117
The current review focuses on delivery systems for Cas9 mRNA, Cas9 protein, or vectors encoding the Cas9 gene and corresponding sgRNA. Non-viral delivery of Cas9 appears to help Cas9 maintain its on-target effect and reduce off-target effects, and viral vectors for sgRNA and donor template can improve the efficacy of genome editing and homology-directed repair.Author: Zhi-Yao He, Ke Men, Zhou Qin, Yang Yang, Ting Xu, Yu-Quan Wei
https://www.researchgate.net/publication/323211203_Non-viral_gene_delivery_systems_for_tissue_repair_and_regeneration
Non-viral gene delivery systems (nVGDS) have great potential for TE and have several advantages over viral delivery including lower immunogenicity and toxicity, better cell specifcity, better ...
https://www.sciencedirect.com/science/article/pii/S0142961218302862
LNP-INT01 was a biodegradable non-viral delivery system and can be cleared from the body, which minimized the undesired prolonged duration of CRISPR/Cas9 in cells after gene editing and reduced the off-target effect associated with CRISPR/Cas9-based genome editing.Author: Ling Li, Ling Li, Shuo Hu, Xiaoyuan Chen
https://www.slideshare.net/Aparajitha_Anne/gene-delivery-system
May 19, 2012 · Inorganic Nanoparticles:It one of the non-viral gene delivery system where we use gold .silicaand iron oxide and calcium phosphate some of the benefits are storagestability, low manufacturing cost and often time, low immunogenicity.
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