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https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2096447/
Dec 03, 2007 · Nonviral delivery strategies for siRNA in vivo. Viral vectors are highly efficient delivery systems for nucleic acids, but their clinical application is hindered by their induction of toxic immune responses and inadvertent gene expression changes following random integration into the host genome, and as such, they are not covered further here (see instead ref. 10).Author: Saghir Akhtar, Ibrahim F. Benter
https://www.jci.org/articles/view/33494
Other in vivo delivery approaches for siRNAs include aptamer-siRNA conjugates that specifically inhibit tumor growth and mediate tumor regression in a xenograft model of prostate cancer and the use of a chitosan-based siRNA nanoparticle delivery system to knockdown EGFP both in vivo and in vitro .
https://dm5migu4zj3pb.cloudfront.net/manuscripts/33000/33494/cache/33494.1-20150304094708-covered-253bed37ca4c1ab43d105aefdf7b5536.pdf
Nonviral delivery of synthetic siRNAs in vivo Saghir Akhtar1,2 and Ibrahim F. Benter2 1SA Pharma, Sutton Coldfield, West Midlands, United Kingdom. 2Department of Pharmacology and Toxicology, Faculty of Medicine, Kuwait University Health Sciences Center, Safat, Kuwait.
https://www.semanticscholar.org/paper/Nonviral-delivery-of-synthetic-siRNAs-in-vivo.-Akhtar-Benter/0027911a04242f0b67f5fb56076e00124a104519
Nonviral delivery of synthetic siRNAs in vivo. @article{Akhtar2007NonviralDO, title={Nonviral delivery of synthetic siRNAs in vivo.}, author={Saghir Akhtar and Ibrahim F. Benter}, journal={The Journal of clinical investigation}, year={2007}, volume={117 12}, pages={ 3623-32 } } ... Toxicogenomics of non-viral drug delivery systems for RNAi ...
https://europepmc.org/articles/PMC2096447
Dec 01, 2007 · Europe PMC is an archive of life sciences journal literature.Author: Saghir Akhtar, Ibrahim F. Benter
https://onlinelibrary.wiley.com/doi/full/10.1002/anie.201610209
Dec 16, 2016 · ZNP delivery of mRNA results in high protein expression at low doses in vitro (<600 pM) and in vivo (1 mg kg −1). Intravenous co‐delivery of Cas9 mRNA and sgLoxP induced expression of floxed tdTomato in the liver, kidneys, and lungs of engineered mice.Author: Jason B. Miller, Shuyuan Zhang, Petra Kos, Hu Xiong, Kejin Zhou, Sofya S. Perelman, Hao Zhu, Daniel ...
https://www.intechopen.com/books/rna-interference/non-viral-sirna-and-shrna-delivery-systems-in-cancer-therapy
Viral delivery systems have serious problems. Therefore, non-viral systems are more attractable than viral systems for siRNAs. Cationic lipids, liposomes, and polymers such as chitosan, PEI, PLL, and PLGA are used as non-viral siRNA delivery system. However, more suitable carriers are needed for siRNA delivery systems.Author: Emine Şalva, Ceyda Ekentok, Suna Özbaş Turan, Jülide Akbuğa
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2692493/
Jun 01, 2009 · A number of nonviral siRNA delivery approaches have now been reported in vivo, including in nonhuman primates and humans 6 – 14. Non-viral vectors for siRNA delivery Of primary consideration in deciding on a drug delivery system for siRNA is whether the intended disease target lends itself to systemic or local administration.Author: Kun Gao, Leaf Huang
https://www.sciencedirect.com/science/article/pii/S0168365915302832
A chemically diverse suite of delivery materials with origins as materials for cellular transfection of DNA and small interfering RNAs (siRNAs) has recently been reported to have promise as non-viral delivery agents for mRNA.Author: Kevin J. Kauffman, Matthew J. Webber, Matthew J. Webber, Daniel G. Anderson
https://www.researchgate.net/publication/11746751_Gene_delivery_with_synthetic_non_viral_carriers
Non-viral gene delivery involving the use of cationic polymer and cationic lipid based carriers still continues to enjoy a high profile due to the safety advantages offered by these systems when ...
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