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https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3507026/
Jul 06, 2012 · INTRODUCTION. Basically gene therapy is an intracellular delivery of genomic materials (transgene) into specific cells to generate a therapeutic effect by correcting an existing abnormality or providing the cells with a new function.[] Different types of gene delivery systems may be applied in gene therapy to restore a specific gene function or turning off a special gene(s).
https://www.intechopen.com/books/gene-therapy-tools-and-potential-applications/non-viral-delivery-systems-in-gene-therapy
Gene delivery systems include viral vectors and non-viral vectors. Viral vectors are the most effective, but their application is limited by their immunogenicity, oncogenicity and the small size of the DNA they can transport. Non-viral vectors are safer, of low cost, more reproducible and do not present DNA size limit.Author: Alicia Rodríguez Gascón, Ana del Pozo-Rodríguez, María Ángeles Solinís
https://www.intechopen.com/books/recent-advances-in-novel-drug-carrier-systems/gene-delivery-systems-recent-progress-in-viral-and-non-viral-therapy
Non-viral gene delivery systems were developed as an alternative to viral-based systems. One of the most important advantages of these systems is that they develop transfection. Non-viral gene delivery systems are divided into two categories: physical and chemical.Author: Erdal Cevher, Ali Demir Sezer, Emre Şefik Çağlar
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4347098/
Jan 01, 2015 · The major advantage of using non-viral vectors is its bio-safety. However the application of non-viral gene transfer have been ignored for a long time in past because of their poor efficiency of delivery thereby low transient expression of their transgenes . Non-viral vectors have drawn significant attention due to its less immunotoxicity.Author: Murali Ramamoorth, Aparna Narvekar
https://www.sciencedirect.com/science/article/pii/S0142961218302862
This issue is very important for targeted gene editing efficacy as well as the off-target probability in other tissues. In the past decades, there have been extensive efforts on facilitating particles accumulation in the targeted tissues for non-viral delivery vectors-mediated gene therapy [155,156]. We assume that these strategies can also be ...Author: Ling Li, Ling Li, Shuo Hu, Xiaoyuan Chen
https://www.researchgate.net/publication/233841223_Viral_and_nonviral_delivery_systems_for_gene_delivery
Although numerous viral and nonviral gene delivery systems have been developed in the last 3 decades, no delivery system has been designed that can be applied in gene therapy of all kinds of cell ...
https://www.sciencedirect.com/topics/medicine-and-dentistry/non-viral-vector
Non-viral vectors. Gene delivery based on non-viral vectors has attracted much attention due to their universal application range and high safety level of delivery. 5 A number of nanoparticle delivery systems based on polymers and liposomes have been developed. Furthermore, physical approaches including, for example, electroporation and gene ...
https://seekingalpha.com/article/4305556-gene-therapy-series-2-delivery-systems-in-gene-therapy-including-viral-vectors
Nov 11, 2019 · Non-viral methods of transgene delivery. Although viral vectors are being used in two-third of gene therapy programs, there are some non-viral methods of …
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