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https://www.sciencedirect.com/science/article/pii/S0169409X01001624
For example, nasal vaccine delivery is superior to oral delivery in inducing specific immunoglobulin A (IgA) and IgG responses in the upper respiratory tract . Consequently, the rational design of nasal vaccines for clinical use depends on the availability of information about the inductive conditions and in particular, the migratory properties ...
https://www.ncbi.nlm.nih.gov/pubmed/8863138
1. J Drug Target. 1996;3(6):455-67. Nasal delivery of vaccines. Almeida AJ(1), Alpar HO. Author information: (1)Unidade de Ciências eTecnologia Farmacêuticas, Faculdade de Farmácia, Universidade de Lisboa, Portugal. Only relatively recently the significance of inducing not only systemic immunity but also significant local immunity at susceptible mucosal surfaces has become appreciated.Author: A. J. Almeida, H. O. Alpar
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3539070/
Jul 12, 2012 · They have been demonstrated to be efficient nasal delivery systems for several antigens, including DNA , and influenza [77, 78] and HIV proteins . Particulate systems are promising for the nasal delivery of vaccines, enhancing uptake by antigen-presenting cells, conferring a depot effect and protecting the antigen from degradation.Author: Mehfuz Zaman, Saranya Chandrudu, Istvan Toth
https://www.sciencedirect.com/science/article/pii/B9780323399814000154
The aerosol route of delivery of vaccines is one of the most preferred for nasal administration compared with other nasal dosage forms and also less reactogenic than the subcutaneous route of administration. 110 Aerosol vaccination via the lungs targets an epithelium critical to host defense against inhaled pathogens and provides an exciting ...Author: M. Ramvikas, M. Arumugam, S.R. Chakrabarti, K.S. Jaganathan
https://www.nature.com/articles/s41541-020-0172-y
Mar 24, 2020 · a Schematic diagram of the nasal vaccination of immunogen protein using SeV vector. The vector encodes the signal peptide combined with human P301S mutant tau …Author: Hiroki Takeuchi
https://www.webmd.com/a-to-z-guides/prevention-15/vaccines/flu-vaccine-which-type
There are two options: the flu shot and the nasal spray FluMist. Most years, both offer about the same level of protection, but some people are better suited for the shot, while others do better ...
https://www.researchgate.net/publication/234125297_Strategies_for_intranasal_delivery_of_vaccines
Strategies for intranasal delivery of vaccines Article (PDF Available) in Drug Delivery and Translational Research 3(1):100-109 · February 2013 with 228 Reads How we measure 'reads'
https://www.tandfonline.com/doi/abs/10.3109/10611869609015965
Sep 18, 2014 · This review describes the formulation of vaccines to be delivered to one of MALT components, i.e. the nasal-associated lymphoid tissue (NALT), which bears some similarities with the Peyer's patches of the intestine. The association of antigens with adjuvants and particulate carriers such as microparticles, nanoparticles and liposomes is emphasised.Author: A. J. Almeida, H. O. Alpar
https://www.al.com/news/2020/03/uab-to-study-potential-covid-19-vaccine-in-mice.html
12 days ago · Several companies are trying to develop COVID-19 vaccines, but Altimmune is the only one proposing an intranasal spray. Scot Roberts, chief scientific officer for Altimmune, said that type has ...
https://www.optinose.com/exhalation-delivery-systems/nasal-delivery-challenges
Optinose Exhalation Delivery Systems use a unique Bi-Directional™ mechanism of action designed to reliably and effectively deliver medications or vaccines high and deep throughout the nasal passages. References [1] Djupesland PG. Nasal drug delivery devices: characteristics and performance in a clinical perspective—a review.
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