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https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4476983/
Mar 24, 2015 · Research on intranasal delivery of drugs, peptides, and proteins has grown over the past decade as an alternate way to deliver these compounds to the brain. The blood–brain barrier (BBB) limits the ability of most biologicals to enter the central nervous system (CNS).Author: M. Elizabeth Meredith, Therese S. Salameh, William A. Banks
https://juniperpublishers.com/gjpps/pdf/GJPPS.MS.ID.555569.pdf
Global ournl of harc harceutical ciences How to cite this article: Darshana S , June S. Nasal Delivery of Proteins and Peptides. Glob J Pharmaceu Sci. 2017; 1(4) : 555569. DOI: 10.19080/ 002002 GJPPS.2017.01.555569 Delivery of insulin from nose to the distal regions of the
https://www.sciencedirect.com/science/article/pii/016777999190091U
Peptides and proteins are particularly suscep- tible to hydrolysis of amide bonds and oxidation of disulphide bonds. There are several ways in which the molecular structure of such molecules could possibly be modified in order to prevent enzymatic degradation of peptides in the nasal cavity and hence possibly increase the absorption (Table 1).Author: Lisbeth Illum
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3374550/
Nasal routes route of delivery: A drug delivery route that is less technologically demanding than pulmonary delivery is nasal delivery. By virtue of relatively rapid drug absorption, possible bypassing of presystemic clearance and relative ease of administration, delivery of drug by the nasal route offers an attractive alternative for administering systemically active drugs.
https://www.sciencedirect.com/science/article/pii/B9780123849359100033
Nasal delivery of peptides and proteins offers significantly lower drug degradation and metabolism than oral administration. However, the limitations of the nasal route have to be overcome; mainly the nasal epithelium and the rapid mucociliary clearance. Mucoadhesive polymers have the advantage of decreasing mucociliary clearance.Author: Garnpimol C. Ritthidej
https://www.researchgate.net/publication/324160403_Nasal_Delivery_of_Proteins_and_Peptides
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https://www.researchgate.net/publication/6963259_Intravail_Highly_effective_intranasal_delivery_of_peptide_and_protein_drugs
Based on this retrospective analysis, key considerations for nasal peptides formulations were proposed to guide drug discovery and development for intranasal delivery of peptides. View Show abstract
https://link.springer.com/article/10.1208/s12248-015-9719-7
Mar 24, 2015 · Intranasal delivery of proteins and peptides to the CNS provides a means to bypass the BBB in the treatment of neurodegenerative diseases like Alzheimer’s disease (AD). However, simply enabling them to enter the brain is not enough to ensure that it will have a beneficial effect on CNS functions such as cognition.Author: M. Elizabeth Meredith, Therese S. Salameh, William A. Banks
https://www.alzforum.org/news/research-news/sniff-therapeutic-peptides-through-nose
Jul 12, 2007 · A: Certainly some amount of peptide following nasal delivery is absorbed into the blood stream via the nasal, bronchial and alveolar epithelium. However, we measured peptide concentrations after nasal administration concurrently in blood and found that, except for vasopressin, the concentrations were negligible compared with those in CSF.
https://www.tandfonline.com/doi/abs/10.1517/17425247.3.4.529
Jun 19, 2013 · Recent development of a new class of patented alkylsaccharide transmucosal delivery enhancement agents, ... ™, nasal insulin, non-invasive drug delivery, peptide drugs, protein drugs, systemic drug delivery, therapeutic peptides, therapeutic proteins, ... Nasal-nanotechnology: revolution for efficient therapeutics delivery. Amrish Kumar et al.Author: Edward T Maggio
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