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https://www.researchgate.net/publication/5633360_Nanoparticles_as_Nonviral_Gene_Delivery_Vectors
Nanoparticles as Nonviral Gene Delivery Vectors Article · Literature Review (PDF Available) in IEEE Transactions on NanoBioscience 6(4):319-30 · January 2008 with 444 Reads How we measure 'reads'
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4046008/
May 21, 2014 · Non-viral vectors. In considering the viral gene delivery vector safety concerns regarding the risk of excessive immune response (adenovirus) and insertion mutagenesis (retroviruses), the use of non-viral vectors can overcome the mentioned safety problems [].Non-viral vectors either consist of natural vectors (plasmid DNA or small nucleic acids, antisense oligonucleotides, small interfering ...Author: Solmaz Maleki Dizaj, Samira Jafari, Ahmad Yari Khosroushahi
http://www.ijper.org/sites/default/files/IJPER_44_2_1.pdf
gene transfection rate. The two main types of vectors that are used in gene therapy are based on viral or non-viral gene delivery systems. The viral gene delivery system shows a high transfection yield but it has many disadvantages, such as oncogenic effects and immunogenicity. In the present communication, we report on a new gene delivery system
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3879331/
The development of safe and efficient gene carriers is the key to the clinical success of gene therapy. The present study was designed to develop and evaluate the chitosan-graft-polyethylenimine (CP)/DNA nanoparticles as novel non-viral gene vectors for gene therapy of osteoarthritis.Author: Huading Lu, Yuhu Dai, Lulu Lv, Huiqing Zhao
https://www.sciencedirect.com/science/article/abs/pii/S0010854518301127
Gene delivery for molecular-level therapeutics is regarded as a prospective remedial route to cure human diseases by the medical community. The major challenge for delivering genes in vivo is the lack of suitable delivery vehicles possessing high transfection efficiencies and low cytotoxicity. Currently, viral vectors such as retroviruses, lentiviruses, adenoviruses, adeno-associated viruses ...Author: Guimiao Lin, Li Li, Nishtha Panwar, Jie Wang, Swee Chuan Tjin, Xiaomei Wang, Ken-Tye Yong
https://www.sciencedirect.com/science/article/pii/S0142961216303179
Gold nanoparticles (AuNPs) have emerged as attractive non-viral gene vectors. However their application in regenerative medicine is still limited partially due to a lack of an intrinsic capacity to transfect difficult-to-transfect cells such as primary cells or stem cells.Author: Li-Hua Peng, Li-Hua Peng, Yan-Fen Huang, Chen-Zhen Zhang, Jie Niu, Ying Chen, Yang Chu, Zhi-Hong Jia...
https://www.researchgate.net/publication/286369138_Nanoparticles_as_Non-Viral_Gene_Delivery_Vectors
Request PDF Nanoparticles as Non-Viral Gene Delivery Vectors Gene therapy is being considered as a potential medical revolution. Initially, it was viewed as an approach for treating hereditary ...
https://www.intechopen.com/books/gene-therapy-tools-and-potential-applications/non-viral-delivery-systems-in-gene-therapy
Gene delivery systems include viral vectors and non-viral vectors. Viral vectors are the most effective, but their application is limited by their immunogenicity, oncogenicity and the small size of the DNA they can transport. Non-viral vectors are safer, of low cost, more reproducible and do not present DNA size limit.Author: Alicia Rodríguez Gascón, Ana del Pozo-Rodríguez, María Ángeles Solinís
https://www.nature.com/articles/nrg3763
Jul 15, 2014 · Synthetic delivery vectors have the potential to address many of the limitations of viral vectors, particularly with respect to safety. For systemic delivery of DNA, both lipid-based vectors and ...Author: Hao Yin, Rosemary L. Kanasty, Ahmed A. Eltoukhy, Arturo J. Vegas, Arturo J. Vegas, J. Robert Dorkin,...
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